Browsing School of Medicine by Title
Now showing items 273-292 of 553
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Human NCR3 gene variants rs2736191 and rs11575837 influence susceptibility to the longitudinal development of pediatric severe malarial anemia
(Research square, 2022)Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb) < 5.0g/dL] is the most common clinical manifestation ... -
Identity, Preparation, Dosages and Conservation Knowledge of the Antidiabetic Herbs Used by The Tugen Living in Baringo County-Kenya
(African Journal of Health Sciences, 2020)The primary goal of managing Diabetes Mellitus (DM) is to regulate blood sugar levels within the physiologic limits (3Mmol/l to7Mmmol/l-fasting blood sugars). This can be either done pharmacologically (conventional or ... -
Immediate postoperative pain management in adult patients following orthopaedic surgery at the Kenyatta national hospital
(University of Nairobi, 2007)Background: Postoperative pain is a major challenge in the care of surgical patients yet pain therapy is a central medical task and a legal duty and optimum pain control is a fundamental right for all patients. Objective: ... -
Immunization of Rabbits with a Quadrivalent Shigella Bioconjugate Vaccine Induces Functional Antibodies Reactive with Shigella Isolates from Kenya
(American Society for Microbiology, 2022)Diarrheal diseases are a leading cause of global morbidity and mortality, disproportionately affecting children in resource-limited settings. Although improvements in hygiene and access to clean water are helpful, vaccines ... -
Immunogenicity of the RTS, S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial
(Elsevier, 2015)Background The RTS,S/AS01 malaria vaccine targets the circumsporozoite protein, inducing antibodies associated with the prevention of Plasmodium falciparum infection. We assessed the association between anti-circumsporo ... -
Immunohistochemical Analysis of Prostein in Needle Core Biopsies of Acinar and Intraductal Prostatic Adenocarcinoma in Western Kenya Population
(Fortune Journals, 2022)Prostein is a newly reported prostate cancer biomarker. Nonetheless, no reports on African population are available. The current study aimed to determine the prostein expression in archived prostatic core biopsies in Western ... -
Immunophenotypic Characterization of ART- naive, HIV Infected Adults in Kombewa Sub-county, Kisumu: A Cross Sectional Study of Rural Population in Western Kenya
(Journal of Clinical Immunology and Research, 2020)Reliable information on clinical immunophenotypic biomarkers is critical in the management of Hepatitis B and C infections especially in ART naive HIV positive adults. CD4 cell counts and the level of liver function ... -
Immunophenotypic Characterization of ART-naive, HIV Infected Adults in Kombewa Sub-county, Kisumu: A Cross Sectional Study of Rural Population in Western Kenya
(Journal of Clinical Immunology and Research, 2020-11-12)Reliable information on clinical immunophenotypic biomarkers is critical in the management of Hepatitis B and C infections especially in ART naive HIV positive adults. CD4 cell counts and the level of liver function ... -
The impact of microbial keratitis on quality of life in Uganda
(BMJ Specialist Journals, 2019)Background Microbial keratitis (MK) is a frequent cause of sight loss in sub-Saharan Africa. However, no studies have formally measured its impact on quality of life (QoL) in this context. Methods As part of a nested ... -
Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial.
(Pub Med Central, 2009-11-17)OBJECTIVE: RTS,S, a candidate vaccine for malaria, is a recombinant protein expressed in yeast containing part of the circumsporozoite protein (CSP) sequence of 3D7 strain of Plasmodium falciparum linked to the hepatitis ... -
Impact of sulfadoxine-pyrimethamine resistance on effectiveness of intermittent preventive therapy for malaria in pregnancy at clearing infections and preventing low birth weight
(Oxford University Press, 2016-02-01)Owing to increasing sulfadoxine-pyrimethamine (SP) resistance in sub-Saharan Africa, monitoring the effectiveness of intermittent preventive therapy in pregnancy (IPTp) with SP is crucial -
improving household knowledge and and attitude on water, sanitation and hygiene practice through school health programme in nyakach kisumu county in western Kenya
(Journal of Anthropology, 2014)The global problem of access to improved sanitation and water management practices has been compounded by the gap existing between knowledge and practice as well as attitude. The aim of this study was to assess households' ... -
In vitro evaluation of chloroquine-loaded and heparin surface-functionalized solid lipid nanoparticles
(BioMed Central, 2018-12-01)Use of chloroquine, an otherwise safe and relatively affordable anti-malarial drug, was discontinued due to widespread prevalence of resistant parasites. Many entrant anti-malarial drugs for treatment of chloroquine resistant ... -
In vitro interstitial (Leydig) cell response to LH and concentrations of plasma testosterone and LH in the naked mole rat (Heterocephalus glaber, Ruppell)
(Blackwell Publishing Ltd, 1991-03-01)Summary Reproductive endocrinology of the male naked mole rat (Heterocephalus glaber) caught in the wild was studied. In vitro treatment of isolated Leydig cells using either normal dose of LH capable of stimulating ... -
In vivo and in vitro effects of graded doses of the pesticide heptachlor on female sex steroid hormone production in rats
(Pergamon, 1995-05-01)Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental ... -
In-vitro activity of artemether, lumefantrine, dihydroartemisinin and piperaquine against Plasmodium falciparum clinical isolates transported in a formulated transport medium
(Journal of Natural Sciences Research, 2016)Introduction: Development of resistance to antimalarials has emerged as one of the greatest challenges facing malaria control today. In vitro drug sensitivity relies on the growth of plasmodium in the presence of ... -
Increased deposition of C3b on red cells with low CR1 and CD55 in a malaria-endemic region of western Kenya: Implications for the development of severe anemia
(BioMed Central, 2010)Severe anemia due to Plasmodium falciparum malaria is a major cause of mortality among young children in western Kenya. The factors that lead to the age-specific incidence of this anemia are unknown. Previous studies have ... -
Influence of changing day secondary into boarding on students’ participation in public secondary schools in Trans Nzoia West, Kenya
(University of Nairobi, 2015)Changing day secondary into boarding schools is an emerging trend in education sector in Kenya. This trend however tends to affect students’ participation in education. This study was conducted in schools that changed from ... -
INFLUENCE OF DIGITAL MARKETING STRATEGIES ON PERFORMANCE OF CUTFLOWERS EXPORTING FIRMS IN KENYA
(University of Nairobi, Kenya, 2016)Digital marketing is one of the strategies used by firms for marketing communication and products promotion. Digital marketing contributes to the marketing mix by connecting with clients and creating leads to new business ... -
Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in Kenyan children
(PubMed, 2019)Severe malarial anaemia (SMA) is a leading cause of childhood mortality in holoendemic Plasmodium falciparum regions.