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Polymorphisms in the Fc Gamma Receptor IIIA and Toll-Like Receptor 9 Are Associated with Protection against Severe Malarial Anemia and Changes in Circulating Gamma Interferon Levels
(American Society for Microbiology, 2012)
An understanding of the immunogenetic basis of naturally acquired immunity to Plasmodium falciparum infection would aid in the designing of a rationally based malaria vaccine. Variants within the Fc gamma receptors (FcγRs) ...
Temporal genetic differentiation in Glossina pallidipes tsetse fly populations in Kenya
(BioMed Central, 2017-12)
Glossina pallidipes is a major vector of both Human and Animal African Trypanosomiasis
(HAT and AAT) in Kenya. The disease imposes economic burden on endemic regions in
Kenya, including south-western Kenya, which has ...
Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya
(BioMed Central, 2017-04-20)
Background Naturally-acquired immunity to Plasmodium falciparum malaria develops after
several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG)
antibodies and mediate phagocytosis of ...
Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area...
(BioMed Central, 2017-04-20)
Background Improved understanding of the molecular mechanisms involved in pediatric
severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel
therapeutics. Identification of host genetic ...
Multiple evolutionary origins of Trypanosoma evansi in Kenya
(Public Library of Science, 2017-09-07)
Trypanosoma evansi is the parasite causing surra, a form of trypanosomiasis in
camels and other livestock, and a serious economic burden in Kenya and many other parts
of the world. Trypanosoma evansi transmission can ...
Assessment of community health volunteers’ knowledge on cervical cancer in Kadibo Division, Kisumu County: a cross sectional survey
(BioMed Central, 2017-12)
Globally, cervical cancer is the fourth most frequent cancer in women, with an estimated
530,000 new cases in 2012, representing 7.5% of all female cancer deaths. Of the estimated
more than 270,000 deaths from cervical ...
HAPLOTYPES WITHIN NFKBIA PROMOTER ARE ASSOCIATED WITH SEVERE MALARIAL ANEMIA AND CIRCULATING IL-10 AND IP-10 LEVELS IN CHILDREN...
(AMER SOC TROP MED & HYGIENE, 2017-11-01)
HAPLOTYPES WITHIN NFKBIA PROMOTER ARE ASSOCIATED WITH SEVERE MALARIAL ANEMIA AND CIRCULATING IL-10 AND IP-10 LEVELS IN CHILDREN WITH PLASMODIUM FALCIPARUM MALARIA
HIV-1 protease inhibitor drug resistance in Kenyan antiretroviral treatment-naive and-experienced injection drug users and non-drug users
(BioMed Central, 2015-08-15)
Background Although injection drug use drives antiretroviral drug resistance, the prevalence
of protease inhibitor (PI) resistance among Kenyan IDUs remains undetermined. We,
therefore, explored PI resistance mutations ...
HIV-1 protease inhibitor drug resistance in Kenyan antiretroviral treatment-naive and-experienced injection drug users and non-drug users
(BioMed Central, 2015-08-11)
Background Although injection drug use drives antiretroviral drug resistance, the prevalence
of protease inhibitor (PI) resistance among Kenyan IDUs remains undetermined. We,
therefore, explored PI resistance mutations ...
Reduced transplacental transfer of a subset of Epstein-Barr virus-specific antibodies to neonates of mothers infected with Plasmodium falciparum malaria during pre...
(American Society for Microbiology, 2015-11-01)
Over 35% of children in a region of malaria endemicity are infected with Epstein-
Barr virus (EBV) by 6 months of age. This susceptibility may be linked to impaired
transplacental transfer of antibodies. In this study, ...