Browsing by Author "Ouma, Collins"
Now showing items 21-40 of 48
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HAPLOTYPES WITHIN THE NFKB1 PROMOTER ARE ASSOCIATED WITH RISK OF SEVERE MALARIAL ANEMIA
Munde, Elly O; Karim, Zachary S; Onyambu, Frank G; Raballah, Evans O; Ong'echa, John M; Ouma, Collins; Kempaiah, Prakasha; Perkins, Douglas J (AMER SOC TROP MED & HYGIENE, 2015-10-01)Haplotypes within the NFKBI1 promoter are associated with risk of severe malaria anemia -
Hematological predictors of increased severe anemia in Kenyan children coinfected with Plasmodium falciparum and HIV‐1
Davenport, Gregory C; Ouma, Collins; Hittner, James B; Hittner, James B; Ouma, Yamo; Ong'echa, John M; Perkins, Douglas J (Wiley Subscription Services, Inc., A Wiley Company, 2010-04-01)Malaria and HIV-1 are coendemic in many developing countries, with anemia being the most common pediatric hematological manifestation of each disease. Anemia is also one of the primary causes of mortality in children ... -
Hepatitis B virus sero-profiles and genotypes in HIV-1 infected and uninfected injection and Non-injection drug users from coastal Kenya
Webale, Mark K; Budambula, Valentine; Lihana, Raphael; Musumba, Francis O; Nyamache, Anthony K; Budambu, Nancy LM; Ahmed, Aabid A; Ouma, Collins; Were, Tom (BioMed Central, 2015-07-30)Background Information about HBV sero-markers, infection stages and genotypes in HIV-1 infected and uninfected injection and non-injection drug users (IDUs) in Kenya remains elusive. Methods A cross-sectional study ... -
HIV-1 protease inhibitor drug resistance in Kenyan antiretroviral treatment-naive and-experienced injection drug users and non-drug users
Budambula, Valentine; Musumba, Francis O; Webale, Mark K; Kahiga, Titus M; Owuor, Francisca O; Kiarie, James N; Sowayi, George A; Ahmed, Aabid A; Ouma, Collins; Were, Tom (BioMed Central, 2015-08-15)Background Although injection drug use drives antiretroviral drug resistance, the prevalence of protease inhibitor (PI) resistance among Kenyan IDUs remains undetermined. We, therefore, explored PI resistance mutations ... -
HIV-1 protease inhibitor drug resistance in Kenyan antiretroviral treatment-naive and-experienced injection drug users and non-drug users
Budambula, Valentine; Musumba, Francis O; Webale, Mark K; Kahiga, Titus M; Owuor, Francisca O; Kiarie, James N; Sowayi, George A; Ahmed, Aabid A; Ouma, Collins; Were, Tom (BioMed Central, 2015-08-11)Background Although injection drug use drives antiretroviral drug resistance, the prevalence of protease inhibitor (PI) resistance among Kenyan IDUs remains undetermined. We, therefore, explored PI resistance mutations ... -
Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria
Were, T; Otieno, Richard O; Ouma, Collins; Ong'echa, JM; Kelle, Christopher C; Waindi, Eliud N; Michaels, Marian G; Day, Richard D; Vulule, John M; Perkins, DJ (AIDS, 2005)Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria -
Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and-4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
Okumu, Wilson; Okeyo, Winnie A; Munde, Elly O; Raballah, Evans; Anyona, Samuel B; Vulule, John M; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (BioMed Central, 2013-12)In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ... -
Interleukin-6 and interleukin-10 gene promoter polymorphisms and risk of endemic Burkitt lymphoma
Oduor, Cliff I; Chelimo, Kiprotich; Ouma, Collins; Mulama, David H; Foley, Joslyn; Vulule, John; Bailey, Jeffrey A; Moormann, Ann M (The American Society of Tropical Medicine and Hygiene, 2014-09-03)Overexpression of interleukin-6 (IL-6) and IL-10 in endemic Burkitt lymphoma (eBL) may facilitate tumorigenesis by providing a permissive cytokine milieu. Promoter polymorphisms influence interindividual differences ... -
Knowledge and behaviour as determinants of anti-malarial drug use in a peri-urban population from malaria holoendemic region of western Kenya
Watsierah, Carren A; Jura, Walter G; Raballah, Evans; Kaseje, Dan; Abong'o, Benard; Ouma, Collins (BioMed Central, 2011-04-20)The appropriate use of anti-malarial drugs determines therapeutic efficacy and the emergence and spread of drug-resistant malaria. Strategies for improving drug compliance require accurate information about current ... -
Multiple evolutionary origins of Trypanosoma evansi in Kenya
Kamidi, Christine M; Saarman, Norah P; Dion, Kirstin; Mireji, Paul O; Ouma, Collins; Murilla, Grace; Aksoy, Serap; Schnaufer, Achim; Caccone, Adalgisa (Public Library of Science, 2017-09-07)Trypanosoma evansi is the parasite causing surra, a form of trypanosomiasis in camels and other livestock, and a serious economic burden in Kenya and many other parts of the world. Trypanosoma evansi transmission can ... -
MYCOBACTERIUM TUBERCULOSIS RESISTANCE TO ISONIAZID AND RIFAMPICIN IN A HIV-1 ENDEMIC POPULATION IN WESTERN KENYA IN 2014
Likhovole, Clement; Ouma, Collins; Vulule, John; Musau, Susan; Khayumbi, Jeremiah; Okumu, Albert; Murithi, Wilfred (BMJ Specialist Journals, 2017-02-01)Background The spread of mono-resistant and multi-drug resistant tuberculosis (MDR-TB) has been enhanced by delays in the identification of resistant strains. However, resistance gene patterns and the extent and ... -
A non-synonymous polymorphism in IL-23R Gene (rs1884444) is associated with reduced risk to schistosomiasis-associated Immune Reconstitution Inflammatory S...
Ogola, George O; Ouma, Collins; Jura, Walter G; Muok, Erick O; Colebunders, Robert; Mwinzi, Pauline N (BioMed Central, 2014-06-10)Background Human Immunodeficiency Virus (HIV) and Schistosomiasis co-infection is common among residents at the shores of Lake Victoria in Kenya. About 36% of this population initiating antiretroviral therapy (ART) ... -
Polymorphic variability in the 3'untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falc...
Ong'echa, John M; Raballah, Evans O; Kempaiah, Prakasha M; Anyona, Samuel B; Were, Tom; Davenport, Gregory C; Konah, Stephen; Vulule, John M; Ouma, Collins; Hittner, James B; Perkins, Douglas J (BioMed Central, 2011-08-06)Plasmodium falciparum malaria remains a leading cause of morbidity and mortality among African children. Innate immunity provides the first line of defence against P. falciparum infections, particularly in young children ... -
Polymorphisms in the Fc Gamma Receptor IIIA and Toll-Like Receptor 9 Are Associated with Protection against Severe Malarial Anemia and Changes in Circulating Gamma Interferon Levels
Munde, Elly O; Okeyo, Winnie A; Anyona, Samwel B; Raballah, Evans; Konah, Stephen; Okumu, Wilson; Ogonda, Lilian; Vulule, John; Ouma, Collins (American Society for Microbiology, 2012)An understanding of the immunogenetic basis of naturally acquired immunity to Plasmodium falciparum infection would aid in the designing of a rationally based malaria vaccine. Variants within the Fc gamma receptors (FcγRs) ... -
Polymorphisms in the Fc Gamma Receptor IIIA and Toll-Like Receptor 9 Are Associated with Protection against Severe Malarial Anemia and Changes in Circulating...
Okeyo, Winnie; Anyona, Samwel; Raballah, Evan; Konah, Stephen; Ogoda, Lilian; Ouma, Collins (Journals. ASm. org, 2012-10-08)An understanding of the immunogenetic basis of naturally acquired immunity to Plasmodium falciparum infection would aid in the designing of a rationally based malaria vaccine. Variants within the Fc gamma receptors ... -
Presence and distribution of mosquito larvae predators and factors influencing their abundance along the Mara River, Kenya and Tanzania
Dida, Gabriel O; Gelder, Frank B; Anyona, Douglas N; Abuom, Paul O; Onyuka, Jackson O; Matano, Ally-S; Adoka, Samson O; Kanangire, Canisius K; Owuor, Philip O; Ouma, Collins; Ofulla, Ayub VO (Springer International Publishing, 2015-12-01)Among all the malaria controlling measures, biological control of mosquito larvae may be the cheapest and easiest to implement. This study investigated baseline predation of immature mosquitoes by macroinvertebrate ... -
Presence of the knockdown resistance mutation, Vgsc-1014F in Anopheles gambiae and An. arabiensis in western Kenya
Ochomo, Eric; Subramaniam, Krishanthi; Kemei, Brigid; Rippon, Emily; Bayoh, Nabie M; Kamau, Luna; Atieli, Francis; Vulule, John M; Ouma, Collins; Gimnig, John; Donnelly, Martin J; Mbogo, Charles (BioMed Central, 2015-12-01)Conclusion This is the first report of Vgsc-1014F in Kenya. Based on our samples, the mutation is present in low frequencies in both An. gambiae and An. arabiensis. It is important that we start monitoring relative ... -
Provider knowledge of treatment policy and dosing regimen with artemether-lumefantrine and quinine in malaria-endemic areas of western Kenya
Watsierah, Carren A; Onyango, Rosebella O; Ombaka, James H; Abong’o, Benard O; Ouma, Collins (BioMed Central, 2012-12-29)Due to widespread anti-malarial drug resistance in many countries, Kenya included, artemisinin-based Combination Therapy (ACT) has been adopted as the most effective treatment option against malaria. Artemether-lumefantrine ... -
Pyrethroid susceptibility of malaria vectors in four Districts of western Kenya
Ochomo, Eric; Bayoh, Nabie M; Kamau, Luna; Atieli, Francis; Vulule, John; Ouma, Collins; Ombok, Maurice; Njagi, Kiambo; Soti, David; Mathenge, Evan; Muthami, Lawrence; Kinyari, Teresa; Subramaniam, Krishanthi; Kleinschmidt, Immo; Donnelly, Martin J; Mbogo, Charles (BioMed Central, 2014-07-04)Increasing pyrethroid resistance in malaria vectors has been reported in western Kenya where long lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) are the mainstays of vector control. To ensure the ... -
Reduced transplacental transfer of a subset of Epstein-Barr virus-specific antibodies to neonates of mothers infected with Plasmodium falciparum malaria during pre...
Ogolla, Sidney; Daud, Ibrahim I; Asito, Amolo; Sumba, Odada P; Ouma, Collins; Vulule, John; Mehta, Saurabh; Rochford, Rosemary (American Society for Microbiology, 2015-11-01)Over 35% of children in a region of malaria endemicity are infected with Epstein- Barr virus (EBV) by 6 months of age. This susceptibility may be linked to impaired transplacental transfer of antibodies. In this study, ...