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Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.

T, Were,; CW, Gichuki; Ong'echa, JM; Ouma, Collins; Anyona, SB; Kempaiah, P; Raballah, E; Davenpor, GC; Konah, SN; Vulule, JM; Hittner, James B; Perkins, DJ (PubMed, 2012)

Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children residing in regions where plasmodium falciparum transmission is holoendemic. Although largely unexplored in children with SMA, ...

Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults

Were, T; Phawong, Chintana; Ouma, Collins; Tangteerawatana, Piyatida; Thongshoob, Jarinee; Mahakunkijcharoen, Yuvadee; Wattanasirichaigoon, Duangrurdee; Perkins, DJ; Khusmith, Srisin (Immunogenetics, 2012)

Polymorphic variability in immune response genes, such as IL12B, encoding the IL-12p40 subunit is associated with susceptibility to severe malaria in African populations. Since the role of genetic variation in conditioning ...

Polymorphisms in Fc gamma receptor (FcγRIIIA-176 F/V) and Toll-like receptor (TLR9 [-1237 T/C]) are associated with protection against severe malarial anemia an...

Munde, Elly O; Okeyo, Winnie A; Anyona, Samwel B; Raballah, Evans; Konah, Stephen; Okumu, Wilson; Ogonda, Lilian; Vulule, John; Ouma, Collins (American Society for Microbiology, 2012-10-08)

Understanding the immunogenetic basis of naturally acquired immunity to Plasmodium falciparum infection would aid in designing a rationally-based malaria vaccine. Variants within the Fc gamma receptors (FcγRs) mediate ...

(− 7402 T/G and-4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels

Okeyo, Winnie A; Munde, Elly O; Okumu, Wilson; Raballah, Evans; Anyona, Samuel B; Vulule, John M; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (Bio Med Central, 2013)

In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb)< 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ...

Upregulation of Peripheral Blood Levels of Immune-Regulatory Interleukin-10 Cytokine in Human Immunodeficiency Virus-infected Compared to Non-infected Pregn...

Musyoki, Stanslaus K; Chelimo, Kiprotich; Mining, Simeon K; Ouma, Collins (2012)

Alterations in the cytokine status have been suggested to be at least partly responsible for the immune tolerance during pregnancy. Indeed, interleukin-10 (IL-10) cytokine is known to control inflammationinduced ...

Social and Demographic Characteristics of HIV-Positive Mother-Infant Pair and Their Association with Mother-To-Child Transmission of HIV in Vihiga, Kakamega, Bu...

Omondi, Maxwell P; Ombaka, James H; Mwau, Matilu; Ouma, Collins (2012)

The World Health Organization report indicates that in 2013~ 35 million people worldwide lived with HIV and AIDS. Of these, 3.2 million were children age< 15 years. The proportion of women living with HIV has remained ...

Dose-Effects of Bednets Impregnated with a Natural Pyrethrins Formulation: Persistence, Feeding Inhibition, and Wash Resistance against Anopheles gambiae ss

Sum, Kefa S; Vulule, John M; Ouma, Collins; Mulaya, Nicholas; Jura, Walter G (2012)

This study evaluated dose-response, persistence, irritancy and wash resistance of mosquito nets treated with a synergized natural pyrethrins-formulation against Anopheles gambiae ss Methods. Multi-filament polyester ...

The Trends of Progesterone Hormone in Advancing Pregnancy of Human Immunodeficiency Virus-infected Women: A Cohort Study in Western Kenya