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Reduced transplacental transfer of a subset of Epstein-Barr virus-specific antibodies to neonates of mothers infected with Plasmodium falciparum malaria during pre...

Ogolla, Sidney; Daud, Ibrahim I; Asito, Amolo; Sumba, Odada P; Ouma, Collins; Vulule, John; Mehta, Saurabh; Rochford, Rosemary (American Society for Microbiology, 2015-11-01)

Over 35% of children in a region of malaria endemicity are infected with Epstein- Barr virus (EBV) by 6 months of age. This susceptibility may be linked to impaired transplacental transfer of antibodies. In this study, ...

MYCOBACTERIUM TUBERCULOSIS RESISTANCE TO ISONIAZID AND RIFAMPICIN IN A HIV-1 ENDEMIC POPULATION IN WESTERN KENYA IN 2014

Likhovole, Clement; Ouma, Collins; Vulule, John; Musau, Susan; Khayumbi, Jeremiah; Okumu, Albert; Murithi, Wilfred (BMJ Specialist Journals, 2017-02-01)

Background The spread of mono-resistant and multi-drug resistant tuberculosis (MDR-TB) has been enhanced by delays in the identification of resistant strains. However, resistance gene patterns and the extent and ...

Pyrethroid susceptibility of malaria vectors in four Districts of western Kenya

Ochomo, Eric; Bayoh, Nabie M; Kamau, Luna; Atieli, Francis; Vulule, John; Ouma, Collins; Ombok, Maurice; Njagi, Kiambo; Soti, David; Mathenge, Evan; Muthami, Lawrence; Kinyari, Teresa; Subramaniam, Krishanthi; Kleinschmidt, Immo; Donnelly, Martin J; Mbogo, Charles (BioMed Central, 2014-07-04)

Increasing pyrethroid resistance in malaria vectors has been reported in western Kenya where long lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) are the mainstays of vector control. To ensure the ...

Sickle cell trait is not associated with endemic Burkitt lymphoma: An ethnicity and malaria endemicity‐matched case–control study suggests factors controlling EBV...

Mulama, David H; Bailey, Jeffrey A; Foley, Joslyn; Chelimo, Kiprotich; Ouma, Collins; Jura, Walter G; Otieno, Juliana; Vulule, John; Moormann, Ann M (2014-02)

Endemic Burkitt lymphoma (eBL) is associated with Epstein–Barr virus (EBV) and Plasmodium falciparum coinfections. Malaria appears to dysregulate immunity that would otherwise control EBV, thereby contributing to eBL ...

Interleukin-6 and interleukin-10 gene promoter polymorphisms and risk of endemic Burkitt lymphoma

Oduor, Cliff I; Chelimo, Kiprotich; Ouma, Collins; Mulama, David H; Foley, Joslyn; Vulule, John; Bailey, Jeffrey A; Moormann, Ann M (The American Society of Tropical Medicine and Hygiene, 2014-09-03)

Overexpression of interleukin-6 (IL-6) and IL-10 in endemic Burkitt lymphoma (eBL) may facilitate tumorigenesis by providing a permissive cytokine milieu. Promoter polymorphisms influence interindividual differences ...

EBNA-1 specific effector T cell deletion associated with holoendemic malaria exposure in the etiology of endemic Burkitt’s lymphoma (P3063)

Mulama, David; Chelimo, Kiprotich; Collins, Ouma; Jura, Walter; Otieno, Juliana; Vulule, John; Munz, Christian; Moormann, Ann (American Association of Immunologists, 2013-05-01)

Etiological mechanism of eBL remain largely unknown despite long-standing epidemiological link between malaria and EBV co-infection. Age-dependent deficiency in EBV-specific CD8+ T cell-mediated IFN-γ immunosurveillance ...

Polymorphisms in Fc gamma receptor (FcγRIIIA-176 F/V) and Toll-like receptor (TLR9 [-1237 T/C]) are associated with protection against severe malarial anemia an...

Munde, Elly O; Okeyo, Winnie A; Anyona, Samwel B; Raballah, Evans; Konah, Stephen; Okumu, Wilson; Ogonda, Lilian; Vulule, John; Ouma, Collins (American Society for Microbiology, 2012-10-08)

Understanding the immunogenetic basis of naturally acquired immunity to Plasmodium falciparum infection would aid in designing a rationally-based malaria vaccine. Variants within the Fc gamma receptors (FcγRs) mediate ...

Sputum Smear Conversion Time of HIV Infected and Uninfected Patients with Rifampicin and Isoniazid Mycobacterium tuberculosis gene Mutations in Western Kenya

Shiluli, Clement; Ouma, Ouma; Vulule, John; Khayumbi, Jeremiah; Murithi, Wilfred; Musau, Susan; Okumu, Albert (2012)

Mono-resistant and multi-drug resistant tuberculosis (MDR-TB) has been enhanced by delays in the identification of resistant strains. However, resistance gene patterns and the extent of monoresistant TB and MDR-TB in ...