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Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya
(BioMed Central, 2017-04-20)
Background Naturally-acquired immunity to Plasmodium falciparum malaria develops after
several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG)
antibodies and mediate phagocytosis of ...
Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area...
(BioMed Central, 2017-04-20)
Background Improved understanding of the molecular mechanisms involved in pediatric
severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel
therapeutics. Identification of host genetic ...
Polymorphisms in Fc gamma receptor (FcγRIIIA-176 F/V) and Toll-like receptor (TLR9 [-1237 T/C]) are associated with protection against severe malarial anemia an...
(American Society for Microbiology, 2012-10-08)
Understanding the immunogenetic basis of naturally acquired immunity to
Plasmodium falciparum infection would aid in designing a rationally-based malaria vaccine.
Variants within the Fc gamma receptors (FcγRs) mediate ...
(− 7402 T/G and-4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
(Bio Med Central, 2013)
In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe
malarial anemia [SMA, hemoglobin (Hb)< 6.0 g/dL, with any density parasitemia] is the most
common clinical manifestation of severe ...
Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia
(BioMed Central, 2023-09-13)
Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb) < 5.0 g/dL in children] is the most common clinical ...