School of Medicine: Recent submissions
Now showing items 441-460 of 553
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Biochemical and molecular diagnosis of glutaric aciduria type 1 in a black South African male child: case report
(East African medical journal, 2001)Glutaric aciduria type I (GA-1) is an inborn error of metabolism caused by a deficiency of the mitochondrial enzyme glutaryl-Co enzyme A dehydrogenase. GA-1 is not uncommon amongst Caucasians but to the best of our knowledge, ... -
Leptin and pre-eclampsia in black African parturients
(Elsevier, 2002-11-01)To measure serum concentrations of the hormone leptin during late pregnancy in Black African women with pre-eclampsia, healthy normotensive pregnant women as controls and healthy normotensive non-pregnant women; secondly, ... -
The effect of different apo (a) isoforms on plasminogen activation in black South African subjects: cardiovascular topics
(Clinics Cardive Publishing, 2003-05-01)The present study evaluates the effect of different apolipoprotein (a)[apo (a)] isoforms on plasminogen activation. -
Serum cystatin C for assessment of glomerular filtration rate in hypertensive disorders of pregnancy
(Taylor & Francis, 2004-01-01)Assessment of renal function is important in the evaluation of the pregnant hypertensive patient. The aim of this study was to evaluate the diagnostic utility of cystatin C as a marker of glomerular filtration rate in ... -
The accuracy of urine dipsticks as a screening test for proteinuria in hypertensive disorders of pregnancy
(Taylor & Francis, 2005-01-01)Proteinuria is used as a criterion in the classification system for hypertensive disorders of pregnancy including preeclampsia. The aim of the study was to evaluate the accuracy of dipstick urinalysis in a single voided ... -
The effect of abdominal obesity on insulin sensitivity and serum lipid and cytokine concentrations in African women
(Blackwell Publishing Ltd, 2006-05)Studies have shown clear associations of abdominal obesity with lipid and glucose metabolism and cytokine levels in a number of different population groups. However, no such studies have been performed in an African ... -
Genetic analysis of HIV-1 subtypes in Nairobi, Kenya
(Public Library of Science, 2008-09-11)Genetic analysis of a viral infection helps in following its spread in a given population, in tracking the routes of infection and, where applicable, in vaccine design. Additionally, sequence analysis of the viral genome ... -
Macro CK in patients with elevated troponin I levels: case report: online article
(Clinics Cardive Publishing, 2012-02-01)CK-MB activity levels can be falsely elevated by the presence of macro CK, especially if immuno-inhibition assays are used in the measurement. In patients with macro CK and cardiac pathology that could result in an elevated ... -
Population-specific evolution of HIV Gag epitopes in genetically diverged patients
(Elsevier, 2013-06-01)Under the host selection pressure HIV evolves rapidly to override crucial steps in the antigen presentation pathway. This allows the virus to escape binding and recognition by cytotoxic T lymphocytes. Selection pressures ... -
HIV-1 progression links with viral genetic variability and subtype, and patient’s HLA type: analysis of a Nairobi-Kenyan cohort
(Springer Berlin Heidelberg, 2014-02-01)In a Nairobi-Kenyan cohort of 50 HIV-1 positive patients, we analysed the prevalence of HIV-1 subtypes and human leucocyte antigen (HLA) alleles. From this cohort, 33 patients were selected for the analysis of HIV-1 infection ... -
Measurement of improvement achieved by participation in international laboratory accreditation in sub-Saharan Africa: the Aga Khan University Hospital Nairobi experience
(Oxford University Press, 2014-02-02)As part of the ISO 15189:2007 accreditation process, the Aga Khan University Hospital Nairobi laboratory became the first internationally accredited hospital laboratory in sub-Saharan Africa outside South Africa in 2011 ... -
Family history as a risk for early-onset type 2 diabetes in Kenyan patients.
(EBSCO Industries, Inc, 2014)Early-onset type 2 diabetes is regarded as disease occurring before the age of 40 years. It is well described, and increasing in prevalence, but there is little information from Africa. We therefore assessed the prevalence ... -
Prevalence of transmitted drug resistance mutations in HIV-1-infected drug-naive patients from urban and suburban regions of Kenya
(Mary Ann Liebert, Inc., 2016-03-01)HIV was first described in Kenya in 1984–1985. Currently, Kenya has an estimated HIV-1 prevalence of 6.2%. With the introduction of antiretroviral drugs, the survival of most HIV patients has been prolonged markedly. ... -
Comparison of equations for estimating glomerular filtration rate in screening for chronic kidney disease in asymptomatic black Africans: a cross sectional study
(BioMed Central, 2017-12)Several equations have been developed to estimate glomerular filtration rate (eGFR). The common equations used were derived from populations predominantly comprised of Caucasians with chronic kidney disease (CKD). Some of ... -
Metabolic syndrome and its predictors in an urban population in Kenya: a cross sectional study
(BioMed Central, 2017-12-01)The metabolic syndrome (MetS) is a clustering of interrelated risk factors which doubles the risk of cardio-vascular disease (CVD) in 5–10 years and increases the risk of type 2 diabetes 5 fold. The identification of ... -
Complete blood count reference intervals from a healthy adult urban population in Kenya
(Public Library of Science, 2018-06-07)There are racial, ethnic and geographical differences in complete blood count (CBC) blood count (CBC) and therefore it is necessary to establish RIs that are population specific. Several studies have been carried out in ... -
Vitamin D status in healthy black African adults at a tertiary hospital in Nairobi, Kenya: a cross sectional study
(BioMed Central, 2018-12-01)Vitamin D has been known since the twentieth Century for its benefits in bone health. Recent observational studies have demonstrated its benefits in infectious diseases such as tuberculosis and non-communicable diseases ... -
Determination of reference intervals for common chemistry and immunoassay tests for Kenyan adults based on an internationally harmonized protocol and up-to-date statistical methods
(Public Library of Science, 2020-07-09)Due to a lack of reliable reference intervals (RIs) for Kenya, we set out to determine RIs for 40 common chemistry and immunoassay tests as part of the IFCC global RI project. -
A study of haemorrhoids as seen at the Kenyatta National Hospital with special reference to asymptomatic haemorrhoids.
(University of Nairobi, 1987)Haemorrhoids is a condition defined as a swelling at the anal margin, a pile. This condition has been known to afflict mankind for a long time having been documented from the time of Hipprocrates. So far it has not been ... -
Anaemia in elderly patients at Kenyatta National Hospital
(University of Nairobi, 1988)The main objective of this work was to study anaemia in elderly patients and hence contribute some baseline data for future possible work in this area. This prospective study covered 63 elderly patients of all types of ...