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Population-specific evolution of HIV Gag epitopes in genetically diverged patients
(Elsevier, 2013-06-01)
Under the host selection pressure HIV evolves rapidly to override crucial steps in the antigen presentation pathway. This allows the virus to escape binding and recognition by cytotoxic T lymphocytes. Selection pressures ...
Assess Functionality of IMCI Spatial Facility Infrastructure and Policy Utilization in Trans-Nzioa County, Kenya
(Open Science Repository Medicine, 2013)
Implementation of integrated management of childhood illness (IMCI), in a comprehensive and holistic approach, forms bench mark for basic child health in promoting celebration of fifth birth day for children below five ...
Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and-4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
(BioMed Central, 2013-12-01)
In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA,
hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ...
The Global Burden of Severe Falciparum Malaria: An Immunological and Genetic Perspective on Pathogenesis
(Springer, New York, NY, 2013)
Plasmodium falciparum malaria is a leading global cause of morbidity and mortality of infectious disease origin. Here, we focus largely on P. falciparum malaria in sub-Saharan Africa since this geographic region bears the ...
Cryptococcus Meningitis in a Cohort of HIV Positive Kenyan Patients: Outcome after Two Weeks of Therapy
(East African Medical Journal, 2013)
Background: Cryptococcus meningitis is the most lethal meningitis in patients with
HIV/AIDS. It is invariably fatal if not treated appropriately and promptly. In sub-
Saharan Africa with the highest prevalence of HIV/AIDS, ...
Same day colposcopic examination and loop electrosurgical excision procedure (LEEP) presents minimal overtreatment and averts delay in treatment of cervical intraepithelial …
(Scientific Research Publishing, 2013-05-08)
Background: Screening for cancer of the cervix at Kenyatta National Hospital (KNH), follows the recommended three-step strategy; Papanicolaou (Pap) smear, colposcopy/biopsy and loop electrosurgical excision procedure ...
An analysis of pregnancy-related mortality in the KEMRI/CDC health and demographic surveillance system in western Kenya
(Public Library of Science, 2013-07-16)
Background Pregnancy-related (PR) deaths are often a result of direct obstetric complications occurring at childbirth. Methods and Findings To estimate the burden of and characterize risk factors for PR mortality, we ...
Red blood cell immune complex binding capacity in children with sickle cell trait (HbAS) living in P. falciparum malaria holoendemic region of Western Kenya
(ARMY MEDICAL RESEARCH UNIT-KENYA APO NEW YORK 09675, 2013)
Malaria infection leads to the formation of circulating immune complexes CICs which have been implicated in the pathogenesis of complicated malaria which includes severe malarial anemia. Children with sickle cell trait ...
Sickle cell trait (HbAS) is associated with increased expression of erythrocyte complement regulatory proteins CR1 and CD55 levels in children
(International Journal of TROPICAL DISEASE & Health, 2013)
Aims: Erythrocyte complement regulatory proteins, complement receptor 1 (CR1) and decay accelerating factor (CD55) protect red blood cells (RBCs) from complement mediated damage by controlling complement activation cascade ...
Isolation, identification and characterization of urinary tract infectious bacteria and the effect of different antibiotics
(Journal of Natural Sciences Research, 2013)
Introduction: Urinary Tract Infection (UTI) defines a condition in which the urinary tract is infected
with a pathogen causing inflammation which is a common, distressing and occasionally life threatening
condition. UTI ...