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Metabolic syndrome and its predictors in an urban population in Kenya: A cross sectional study
(BioMed Central, 2017)
The metabolic syndrome (MetS) is a clustering of interrelated risk factors which doubles the risk of cardio-vascular disease (CVD) in 5–10 years and increases the risk of type 2 diabetes 5 fold. The identification of ...
Developing and implementing a pediatric emergency care curriculum for providers at district level hospitals in Sub-Saharan Africa: a case study in Kenya
(Frontiers, 2017)
Emergency medicine is a relatively new field in sub-Saharan Africa and dedicated training in pediatric emergency care is limited. While guidelines from the African Federation of Emergency Medicine (AFEM) regarding emergency ...
Effects of crude extracts of Solanum nigrum on the Liver pathology and Survival time in Trypanosoma brucei rhodesiense infected mice
(Science Journal Publication, 2013)
Tissue inflammatory damage during trypanosomosis
significantly affects the treatment and prognosis. The current
study investigated the effects of water extracts of Solanum
nigrum (SNE) on the liver pathology and survival ...
Comparison of drug Sensitivity and Pathogenicity of Trypanosoma brucei rhodesiense isolates with their respective clones originating from Busia and Busoga
(Journal of Natural Sciences Research, 2013)
Introduction: Studies using clones in the laboratory show variations in pathogenicity and drug sensitivity
compared to their respective natural isolates for various trypanosome species. This suggests that within isolates
there ...
Reduced interferon (IFN)-α conditioned by IFNA2 (− 173) and IFNA8 (− 884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all …
(Springer-Verlag, 2012)
Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ...
Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
(Springer, 2013)
In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ...
The Global Burden of Severe Falciparum Malaria: An Immunological and Genetic Perspective on Pathogenesis
(Springer, 2012)
Plasmodium falciparum malaria is a leading global cause of morbidity and mortality of infectious disease origin. Here, we focus largely on P. falciparum malaria in sub-Saharan Africa since this geographic region bears the ...
Reduced systemic bicyclo-prostaglandin-E2 and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia
(Wiley Subscription Services, Inc., A Wiley Company, 2012)
In holoendemic Plasmodium falciparum transmission areas, severe malaria primarily occurs in children aged <48 months and manifests as severe malarial anemia [SMA; hemoglobin (Hb) < 6.0 g/dL]. Induction of high levels of ...
Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the Global Rheumatic Heart Disease Registry (the REMEDY study)
(Oxford University Press, 2015)
This prospective registry enrolled 3343 patients (median age 28 years, 66.2% female) presenting with RHD at 25 hospitals in 12 African countries, India, and Yemen between January 2010 and November 2012. The majority (63.9%) ...
Heart disease and stroke statistics—2017 update: a report from the American Heart Association
(Lippincott Williams & Wilkins, 2017)
Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together in a single document ...