Browsing School of Medicine by Author "Raballah, E"
Now showing items 1-7 of 7
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(−7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
Okeyo, WA; Munde, EO; Okumu, W; Raballah, E; Anyona, SB; Vulule, JM; Ong’echa, JM; Perkins, DJ; Ouma, C (Bio Med Central, 2013)In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ... -
Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya.
Munde, EO; Okeyo, WA; Raballah, E; Anyona, SB; Were, T; Ong’echa, JM; Perkins, DJ; Ouma, C (BMC infectious diseases, 2017-04)BACKGROUND: Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG) antibodies and mediate phagocytosis of ... -
Factors associated with non-adherence to Artemisinin-based combination therapy (ACT) to malaria in a rural population from holoendemic region of western Kenya.
Onyango, EO; Ayodo, G; Watsierah, CA; Were, T; Okumu, W; Anyona, SB; Raballah, E; Okoth, JM; Gumo, S; Orinda, GO; Ouma, C (Pub Med Central, 2012-06)Background Over the years, reports implicate improper anti-malarial use as a major contributor of morbidity and mortality amongst millions of residents in malaria endemic areas, Kenya included. However, there are limited ... -
Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children.
Ouma, C; Davenport, GC; Garcia, S; Kempaiah, P; Chaudhary, A; Were, T; Anyona, SB; Raballah, E; Konah, SN; Hittner, JB; Vulule., JM; Ong'echa, JM; Perkins, DJ (Pub Med Central, 2012-02)Development of protective immunity against Plasmodium falciparum is partially mediated through binding of malaria-specific IgG to Fc gamma (γ) receptors. Variation in human FcγRIIA-H/R-131 and FcγRIIIB-NA1/NA2 affect ... -
Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality
Anyona, SB; Kempaiah, P; Raballah, E; Ouma, C; Were, T; Davenport, GC; Konah, SN; Vulule, JM; Hittner, JB; Gichuki, CW; Ong'echa, JM; Perkins, DJ (Pub Med Central, 2011-12)Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children residing in regions where Plasmodium falciparum transmission is holoendemic. Although largely unexplored in children with SMA, ... -
Reduced interferon (IFN)-α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality
Kempaiah, P; Anyona, SB; Raballah, E; Davenport, GC; Were, T; Hittner, JB; Ong'echa JM, JM; Perkins, DJ (Pub Med Central, 2012-08)Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ... -
Reduced Systemic Bicyclo-Prostaglandin-E2 and Cyclooxygenase-2 Gene Expression are Associated with Inefficient Erythropoiesis and Enhanced Uptake of Monocytic Hemozoin in Children with Severe Malarial Anemia
Anyona, SB; Kempaiah, P; Raballah, E; Davenport, GC; Were, T; Konah, SN; Vulule, JM; Hittner, JB; Gichuki, CW; Ong’echa, JM; Perkins, DJ (Pub Med Central, 2012-08)In holoendemic Plasmodium falciparum transmission areas, severe malaria primarily occurs in children <48 mos. and manifests as severe malarial anemia [SMA; hemoglobin (Hb)<6.0 g/dL]. Induction of high levels of prostaglandin-E2 ...