Browsing School of Medicine by Author "Kempaiah, P"
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Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children.
Ouma, C; Davenport, GC; Garcia, S; Kempaiah, P; Chaudhary, A; Were, T; Anyona, SB; Raballah, E; Konah, SN; Hittner, JB; Vulule., JM; Ong'echa, JM; Perkins, DJ (Pub Med Central, 2012-02)Development of protective immunity against Plasmodium falciparum is partially mediated through binding of malaria-specific IgG to Fc gamma (γ) receptors. Variation in human FcγRIIA-H/R-131 and FcγRIIIB-NA1/NA2 affect ... -
Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality
Anyona, SB; Kempaiah, P; Raballah, E; Ouma, C; Were, T; Davenport, GC; Konah, SN; Vulule, JM; Hittner, JB; Gichuki, CW; Ong'echa, JM; Perkins, DJ (Pub Med Central, 2011-12)Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children residing in regions where Plasmodium falciparum transmission is holoendemic. Although largely unexplored in children with SMA, ... -
Reduced interferon (IFN)-α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality
Kempaiah, P; Anyona, SB; Raballah, E; Davenport, GC; Were, T; Hittner, JB; Ong'echa JM, JM; Perkins, DJ (Pub Med Central, 2012-08)Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ... -
Reduced Systemic Bicyclo-Prostaglandin-E2 and Cyclooxygenase-2 Gene Expression are Associated with Inefficient Erythropoiesis and Enhanced Uptake of Monocytic Hemozoin in Children with Severe Malarial Anemia
Anyona, SB; Kempaiah, P; Raballah, E; Davenport, GC; Were, T; Konah, SN; Vulule, JM; Hittner, JB; Gichuki, CW; Ong’echa, JM; Perkins, DJ (Pub Med Central, 2012-08)In holoendemic Plasmodium falciparum transmission areas, severe malaria primarily occurs in children <48 mos. and manifests as severe malarial anemia [SMA; hemoglobin (Hb)<6.0 g/dL]. Induction of high levels of prostaglandin-E2 ... -
Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia.
Anyona, SB; Kempaiah, P; Davenport, GC; Vulule, JM; Hittner, JB; Ong’echa, JM; Perkins, DJ (Biochemical and biophysical research communications, 2013)In holoendemic Plasmodium falciparum transmission regions, malarial anemia is a leading cause of childhood morbidity and mortality. Identifying biomarkers of malaria disease severity is important for identifying at-risk ...