| dc.contributor.author | Serem Erick Kibichiy, Mburu Jane, Mdachi Raymond, Korir Scolastica, Kibugu James, Kagira John, Ngure Raphael | |
| dc.date.accessioned | 2020-11-30T08:56:58Z | |
| dc.date.available | 2020-11-30T08:56:58Z | |
| dc.date.issued | 2013 | |
| dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/3086 | |
| dc.description.abstract | Tissue inflammatory damage during trypanosomosis
significantly affects the treatment and prognosis. The current
study investigated the effects of water extracts of Solanum
nigrum (SNE) on the liver pathology and survival of Swiss white
mice infected with Trypanosoma brucei rhodesiense.
Trypanosome infected mice treated with SNE had significantly
(P<0.05) increased and dose dependent survival time and liver
pathology. Mice treated with higher concentrations of SNE had
minimal liver pathology with minimal infiltration by
inflammatory cells compared with the dexamethasone treated
and untreated mice which had massive infiltration suggesting
that SNE could be superior to dexamethasone in reducing
trypanosome mediated liver pathology. Therefore, SNE could be
a better anti-inflammatory adjunct in the treatment of Human
African trypanosomosis (HAT) and other inflammatory
conditions such as hepatitis | en_US |
| dc.publisher | Science Journal Publication | en_US |
| dc.subject | Liver pathology; Inflammation; Survival time; Solanum nigrum; Human African Trypanosomosis. | en_US |
| dc.title | Effects of crude extracts of Solanum nigrum on the Liver pathology and Survival time in Trypanosoma brucei rhodesiense infected mice | en_US |
| dc.type | Article | en_US |
