7α-Acetylugandensolide and antimicrobial properties of Warburgia ugandensis extracts and isolates against sweet potato pathogens
Publication Date
2011-06-15Author
Opiyo, Sylvia A
OA Manguro, Lawrence OA
Owuor, Philip Okinda-
Ateka, Elijah M
Lemmen, Peter
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Show full item recordAbstract/ Overview
7α-Acetylugandensolide together with thirteen known drimane-type sesquiterpenes
have been isolated from Warbugia ugandensis bark extracts. Their structures were
established by spectroscopic and physical methods as well as comparison with data
available in the literature. The in vitro antimicrobial activities of the extracts and isolates were
investigated against fungi and bacteria which infect sweet potato. Ethyl acetate extract
exhibited the highest (P≤ 0.05) antifungal and antibacterial activities compared to n-hexane
and methanol extracts. Rhizopus stolonifer was more susceptible to ethyl acetate extract
(inhibition zone= 24.5 mm) than Blitox which was used as a positive control. The minimum
inhibitory concentration (MIC) for the isolates ranged between 12.5 and 200 μg/ml with the
lowest MIC value of 12.5 μg/ml being observed with polygodial against Fusarium solani; …
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- Department of Chemistry [326]