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Genetic and non-genetic sources of variation in natural antibodies titre values among indigenous chicken

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dc.contributor.author JO Khobondo, R Mwakubambanya, CB Wasike, AK Kahi
dc.date.accessioned 2020-08-28T07:56:44Z
dc.date.available 2020-08-28T07:56:44Z
dc.date.issued 2017
dc.identifier.uri https://repository.maseno.ac.ke/handle/123456789/2514
dc.description.abstract Innate immunity plays significant role in combating disease. Improvement of any trait including resistance to disease and infection requires identification of genetic and nongenetic sources of variation. This study aimed at deciphering the factors (both genetic and non-genetic) that confers variation in natural antibodies titres values in indigenous chicken of Kenya. The study was conducted at the Smallholder Indigenous Chicken Improvement Program Research Unit at Egerton University, Kenya. The meta data involving several factors (genotypes, ecotypes, cluster, sex, plate and breed) were analysed. The natural antibodies titre values were measured by indirect enzyme linked immunosorbent assay. Two sample t test for means and variance were compared for breed (RIR and IC) and sex (male and female) using IgG, IgA and IgM natural antibody isotypes titre values as dependant variables. One factor linear model was used to determine source of variation. A mixed model fitting chicken as random variable was used as the final model. For the two sample T test, there was significant difference on means for breed and sex (p= 0.05) for all immunoglobulins isotypes. The T test showed significant difference in variance of breed (p= 0.05) but not sex. However, the indigenous chicken and male chicken had higher variance estimates. Breed effect was significant for IgA (P= 0.0323) but not IgG and IgM. Sex was significant for IgG (P= 0.0279) but insignificant for IgA and IgM. Genotype and ecotype were insignificant while plate was significant respectively for both isotypes. Cluster was significant for IgA but not IgM and IgG. The variance estimate for chicken … en_US
dc.publisher American Journal of Research Communication en_US
dc.subject indigenous chicken, determinants, natural antibodies, variation en_US
dc.title Genetic and non-genetic sources of variation in natural antibodies titre values among indigenous chicken en_US
dc.type Article en_US


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