MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia
| dc.contributor.author | Were, T | |
| dc.contributor.author | Awandare, GA | |
| dc.contributor.author | Martinson, JJ | |
| dc.contributor.author | Ouma, C | |
| dc.contributor.author | Davenport, GC | |
| dc.contributor.author | Ong'echa, JM | |
| dc.contributor.author | Wang, W | |
| dc.contributor.author | L, Leng | |
| dc.contributor.author | RE, Ferrell, | |
| dc.contributor.author | R, Bucala, | |
| dc.contributor.author | DJ, Perkins | |
| dc.date.accessioned | 2018-01-24T13:03:23Z | |
| dc.date.available | 2018-01-24T13:03:23Z | |
| dc.date.issued | 2012 | |
| dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/248 | |
| dc.description.abstract | Severe malarial anemia (SMA) resulting from Plasmodium falciparum infection is one of the leading causes of childhood mortality in sub-Saharan Africa. The innate immune mediator macrophage migration inhibitory factor (MIF) plays a critical role in the pathogenesis of SMA. METHODS: To investigate the influence of MIF genetic variation on susceptibility to SMA, haplotypes of the MIF-173G/C and-794CATT5-8 polymorphisms were examined in a cohort of Kenyan children. RESULTS: A statistically significant relationship between increasing frequencies of longer CATT repeats at-794 and increasing severity of malarial anemia was observed. In addition, there was a strong association between lower MIF concentrations and longer CATT repeats. Multivariate logistic regression analyses demonstrated that the 6G haplotype (ie, MIF-794CATT6/-173G) was associated … | en_US |
| dc.publisher | Journal of Infectious Diseases | en_US |
| dc.title | MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia | en_US |
| dc.type | Article | en_US |
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