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α+-Thalassemia Protects against Anemia Associated with Asymptomatic Malaria: Evidence from Community-Based Surveys in Tanzania and Kenya

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dc.contributor.author Jacobien Veenemans, Pauline EA Andang'o, Erasto V Mbugi, Rob J Kraaijenhagen, David L Mwaniki, Frank P Mockenhaupt, Susanne Roewer, Raimos M Olomi, John F Shao, Jos WM van der Meer, Huub FJ Savelkoul, Hans Verhoef
dc.date.accessioned 2020-08-17T07:56:59Z
dc.date.available 2020-08-17T07:56:59Z
dc.date.issued 2008-08-01
dc.identifier.uri https://repository.maseno.ac.ke/handle/123456789/2141
dc.description.abstract Background. In hospital-based studies, α+-thalassemia has been found to protect against severe, life-threatening falciparum malaria. α+-Thalassemia does not seem to prevent infection or high parasite densities but rather limits progression to severe disease—in particular, severe malarial anemia. We assessed to what extent α+-thalassemia influences the association between mild, asymptomatic Plasmodium falciparum infection and hemoglobin concentration. Methods. The study was based on 2 community-based surveys conducted among afebrile children (0.5–8 years old; n=801) in Kenya and Tanzania. Results. Among children without inflammation (whole-blood C-reactive protein concentration ≤10 mg/L), P. falciparum infection was associated with only small reductions in hemoglobin concentration, and effects were similar across α … en_US
dc.publisher The University of Chicago Press en_US
dc.subject Cell Biology and Immunology Group and 2 Division of Human Nutrition, Wageningen University, Wageningen, 3 Meander Medical Centre, Amersfoort, and 4 University Medical Centre Nijmegen, Nijmegen, The Netherlands; 5 Institute of Tropical Medicine and International Health, Charité–University Medicine Berlin, Berlin, Germany; 6 Kenyan Institute of Medical Research, Nairobi, Kenya; 7 Kilimanjaro Christian Medical Centre, Moshi, Tanzania en_US
dc.title α+-Thalassemia Protects against Anemia Associated with Asymptomatic Malaria: Evidence from Community-Based Surveys in Tanzania and Kenya en_US
dc.type Article en_US


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