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SUN-359 Antenatal Oral Iron Supplementation, FGF23 and Bone Metabolism in Kenyan Women and Their Offspring: A Randomised Controlled Trial

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dc.contributor.author Vickie S Braithwaite, Ayse Y Demir, Martin N Mwangi, Kerry S Jones, Ann Prentice, Andrew M Prentice, Pauline EA Andang’o, Hans Verhoef
dc.date.accessioned 2020-08-14T07:15:26Z
dc.date.available 2020-08-14T07:15:26Z
dc.date.issued 2020-04
dc.identifier.uri https://repository.maseno.ac.ke/handle/123456789/2098
dc.description.abstract Objectives: FGF23 decreases reabsorption and increases phosphate excretion in the kidney and regulates vitamin D metabolism. Maternal iron deficiency may be implicated in the pathogenesis of hypophosphataemia-driven rickets in offspring through perturbed FGF23 expression. We aimed to determine the effect of antenatal oral iron supplementation on maternal and neonatal markers of bone mineral regulation. Methods: 470 rural Kenyan women with singleton pregnancies and haemoglobin concentrations ≥90g/L were randomly allocated to daily, supervised supplementation iron (60mg as ferrous fumarate) or placebo from 13–23 weeks gestational age until 1 month postpartum. We analysed maternal and neonatal plasma samples collected at birth, with primary outcomes being concentrations of FGF23 in its intact form (I-FGF23, the phosphate- and vitamin D-regulating hormone) and its … en_US
dc.publisher Oxford University Press en_US
dc.subject Bone and Mineral Metabolism, Type 2 Diabetes en_US
dc.title SUN-359 Antenatal Oral Iron Supplementation, FGF23 and Bone Metabolism in Kenyan Women and Their Offspring: A Randomised Controlled Trial en_US
dc.type Article en_US


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