| dc.description.abstract | Malaria and HIV-1 are coendemic in many developing countries, with anemia being
the most common pediatric hematological manifestation of each disease. Anemia is also
one of the primary causes of mortality in children monoinfected with either malaria or HIV-1.
Although our previous results showed HIV-1 (+) children with acute Plasmodium falciparum
malaria [Pf (+)] have more profound anemia, potential causes of severe anemia in coinfected
children remain unknown. As such, children with P. falciparum malaria (aged 3–36 months,
n= 542) from a holoendemic malaria transmission area of western Kenya were stratified into
three groups: HIV-1 negative [HIV-1 (−)/Pf (+)]; HIV-1 exposed [HIV-1 (exp)/Pf (+)]; and HIV-1
infected [HIV-1 (+)/Pf (+)]. Comprehensive clinical, parasitological, and hematological
measures were determined upon enrollment. Univariate, correlational, and hierarchical … | en_US |
