dc.description.abstract | Plasmodium falciparum is an important cause of morbidity and mortality in children residing
in holoendemic transmission areas largely from severe malarial anaemia (SMA). Although
overproduction of inflammatory-derived cytokines are implicated in the
immunopathogenesis of severe malaria, the chemokine regulated on activation, normal T-
cell expressed and secreted (RANTES, CCL5) is largely unexplored in the context of
malaria. Additionally, pro-inflammatory cytokines, such as tumour necrosis factor (TNF)-α,
interleukin (IL)-1 and interferon (IFN)-promote increased RANTES production, while anti-
inflammatory cytokines (eg, IL-4, IL-10 and IL-13) down-regulate RANTES biosynthesis.
However, the effect of these cytokines on RANTES production in children with malaria
anaemia (MA) is poorly understood. Although genetic variation in RANTES is associated … | en_US |