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dc.contributor.authorWere, Tom
dc.date.accessioned2018-01-23T13:20:12Z
dc.date.available2018-01-23T13:20:12Z
dc.date.issued2011-08-15
dc.identifier.urihttps://repository.maseno.ac.ke/handle/123456789/203
dc.description.abstractPlasmodium falciparum is an important cause of morbidity and mortality in children residing in holoendemic transmission areas largely from severe malarial anaemia (SMA). Although overproduction of inflammatory-derived cytokines are implicated in the immunopathogenesis of severe malaria, the chemokine regulated on activation, normal T- cell expressed and secreted (RANTES, CCL5) is largely unexplored in the context of malaria. Additionally, pro-inflammatory cytokines, such as tumour necrosis factor (TNF)-α, interleukin (IL)-1 and interferon (IFN)-promote increased RANTES production, while anti- inflammatory cytokines (eg, IL-4, IL-10 and IL-13) down-regulate RANTES biosynthesis. However, the effect of these cytokines on RANTES production in children with malaria anaemia (MA) is poorly understood. Although genetic variation in RANTES is associated …en_US
dc.titleNatural monocytic acquisition of haemozoin and rantes polymorphisms: association with malarial disease outcomes and functional changes in children from Wester...en_US
dc.typeArticleen_US


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