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dc.contributor.authorOng'echa, John M
dc.contributor.authorRaballah, Evans O
dc.contributor.authorKempaiah, Prakasha M
dc.contributor.authorAnyona, Samuel B
dc.contributor.authorWere, Tom
dc.contributor.authorDavenport, Gregory C
dc.contributor.authorKonah, Stephen
dc.contributor.authorVulule, John M
dc.contributor.authorOuma, Collins
dc.contributor.authorHittner, James B
dc.contributor.authorPerkins, Douglas J
dc.date.accessioned2018-01-23T12:54:55Z
dc.date.available2018-01-23T12:54:55Z
dc.date.issued2011-08-06
dc.identifier.urihttps://repository.maseno.ac.ke/handle/123456789/202
dc.description.abstractPlasmodium falciparum malaria remains a leading cause of morbidity and mortality among African children. Innate immunity provides the first line of defence against P. falciparum infections, particularly in young children that lack naturally-acquired malarial immunity, such as the population examined here. Consistent with the fact that elevated interleukin (IL)-12 is an important component of the innate immune response that provides protective immunity against malaria, we have previously shown that suppression of IL-12 in African children is associated with the development of severe malarial anaemia (SMA). Since the role of IL12B variants in conditioning susceptibility to SMA remains largely unexplored, the association between a single nucleotide polymorphism (1188A→ C, rs3212227), SMA (Hb< 6.0 g/dL), circulating IL-12p40/p70 levels, and longitudinal clinical …en_US
dc.publisherBioMed Centralen_US
dc.titlePolymorphic variability in the 3'untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falc...en_US
dc.typeArticleen_US


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