Polymorphic variability in the 3'untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falc...
dc.contributor.author | Ong'echa, John M | |
dc.contributor.author | Raballah, Evans O | |
dc.contributor.author | Kempaiah, Prakasha M | |
dc.contributor.author | Anyona, Samuel B | |
dc.contributor.author | Were, Tom | |
dc.contributor.author | Davenport, Gregory C | |
dc.contributor.author | Konah, Stephen | |
dc.contributor.author | Vulule, John M | |
dc.contributor.author | Ouma, Collins | |
dc.contributor.author | Hittner, James B | |
dc.contributor.author | Perkins, Douglas J | |
dc.date.accessioned | 2018-01-23T12:54:55Z | |
dc.date.available | 2018-01-23T12:54:55Z | |
dc.date.issued | 2011-08-06 | |
dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/202 | |
dc.description.abstract | Plasmodium falciparum malaria remains a leading cause of morbidity and mortality among African children. Innate immunity provides the first line of defence against P. falciparum infections, particularly in young children that lack naturally-acquired malarial immunity, such as the population examined here. Consistent with the fact that elevated interleukin (IL)-12 is an important component of the innate immune response that provides protective immunity against malaria, we have previously shown that suppression of IL-12 in African children is associated with the development of severe malarial anaemia (SMA). Since the role of IL12B variants in conditioning susceptibility to SMA remains largely unexplored, the association between a single nucleotide polymorphism (1188A→ C, rs3212227), SMA (Hb< 6.0 g/dL), circulating IL-12p40/p70 levels, and longitudinal clinical … | en_US |
dc.publisher | BioMed Central | en_US |
dc.title | Polymorphic variability in the 3'untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falc... | en_US |
dc.type | Article | en_US |
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