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dc.contributor.authorOuma, Collins
dc.contributor.authorDavenport, Gregory C
dc.contributor.authorGarcia, Steven
dc.contributor.authorKempaiah, Prakasha
dc.contributor.authorChaudhary, Ateefa
dc.contributor.authorWere, Tom
dc.contributor.authorAnyona, Samuel B
dc.contributor.authorRaballah, Evans
dc.contributor.authorKonah, Stephen N
dc.contributor.authorHittner, James B
dc.contributor.authorVulule, John M
dc.contributor.authorOng’echa, John M
dc.contributor.authorPerkins, Douglas J
dc.description.abstractDevelopment of protective immunity against Plasmodium falciparum is partially mediated through binding of malaria-specific IgG to Fc gamma (γ) receptors. Variations in human FcγRIIA-H/R-131 and FcγRIIIB-NA1/NA2 affect differential binding of IgG sub- classes. Since variability in FcγR may play an important role in severe malarial anemia (SMA) pathogenesis by mediating phagocytosis of red blood cells and triggering cytokine production, the relationship between FcγRIIA-H/R131 and FcγRIIIB-NA1/NA2 haplotypes and susceptibility to SMA (Hb< 6.0 g/dL) was investigated in Kenyan children (n= 528) with acute malaria residing in a holoendemic P. falciparum transmission region. In addition, the association between carriage of the haplotypes and repeated episodes of SMA and all- cause mortality were investigated over a 3-year follow-up period. Since variability in FcγR …en_US
dc.titleFunctional Haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan childrenen_US

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