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dc.contributor.authorMulama, David
dc.contributor.authorChelimo, Kiprotich
dc.contributor.authorCollins, Ouma
dc.contributor.authorJura, Walter
dc.contributor.authorOtieno, Juliana
dc.contributor.authorVulule, John
dc.contributor.authorMunz, Christian
dc.contributor.authorMoormann, Ann
dc.date.accessioned2018-01-23T09:36:01Z
dc.date.available2018-01-23T09:36:01Z
dc.date.issued2013-05-01
dc.identifier.urihttps://repository.maseno.ac.ke/handle/123456789/188
dc.description.abstractEtiological mechanism of eBL remain largely unknown despite long-standing epidemiological link between malaria and EBV co-infection. Age-dependent deficiency in EBV-specific CD8+ T cell-mediated IFN-γ immunosurveillance has been reported in malaria holoendemic exposed children which has been associated with eBL diagnosis. We sought to investigate whether qualitative differences in EBNA-1 specific T cells existed in malaria- exposed children to explain their increased risk for eBL. We conducted a cross-sectional study of healthy children from western Kenya with divergent malaria exposure: Kisumu (holoendemic) and Nandi (hypoendemic) and eBL age-matched patients. T cell effector function was evaluated by multiparameter flow cytometry against T cell lineage markers (CD3, 4, 8, 45RA & CCR7) and functional phenotype (IFN-γ, IL10, IL17 & PD1) to EBNA-1 …en_US
dc.publisherAmerican Association of Immunologistsen_US
dc.titleEBNA-1 specific effector T cell deletion associated with holoendemic malaria exposure in the etiology of endemic Burkitt’s lymphoma (P3063)en_US
dc.typeArticleen_US


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