| dc.description.abstract | Overexpression of interleukin-6 (IL-6) and IL-10 in endemic Burkitt lymphoma (eBL)
may facilitate tumorigenesis by providing a permissive cytokine milieu. Promoter
polymorphisms influence interindividual differences in cytokine production. We
hypothesized that children genetically predisposed for elevated cytokine levels may be more
susceptible to eBL. Using case-control samples from western Kenya consisting of 117 eBL
cases and 88 ethnically matched healthy controls, we tested for the association between
eBL risk and IL-10 (rs1800896, rs1800871, and rs1800872) and IL-6 (rs1800795) promoter
single nucleotide polymorphisms (SNPs) as well as IL-10 promoter haplotypes. In addition,
the association between these variants and Epstein Barr Virus (EBV) load was examined.
Results showed that selected IL-10 and IL-6 promoter SNPs and IL-10 promoter … | en_US |
