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Serratia marcescens is injurious to intestinal epithelial cells

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dc.contributor.author Ochieng, John B
dc.contributor.author Boisen, Nadia
dc.contributor.author Lindsay, Brianna
dc.contributor.author Santiago, Araceli
dc.contributor.author Ouma, Collins
dc.contributor.author Ombok, Maurice
dc.contributor.author Fields, Barry
dc.contributor.author Stine, O Colin
dc.contributor.author Nataro, James P
dc.date.accessioned 2018-01-22T12:27:23Z
dc.date.available 2018-01-22T12:27:23Z
dc.date.issued 2014-11-02
dc.identifier.uri https://repository.maseno.ac.ke/handle/123456789/179
dc.description.abstract Diarrhea causes substantial morbidity and mortality in children in low-income countries. Although numerous pathogens cause diarrhea, the etiology of many episodes remains unknown. Serratia marcescens is incriminated in hospital-associated infections, and HIV/AIDS associated diarrhea. We have recently found that Serratia spp. may be found more commonly in the stools of patients with diarrhea than in asymptomatic control children. We therefore investigated the possible enteric pathogenicity of S. marcescens in vitro employing a polarized human colonic epithelial cell (T84) monolayer. Infected monolayers were assayed for bacterial invasion, transepithelial electrical resistance (TEER), cytotoxicity, interleukin-8 (IL-8) release and morphological changes by scanning electron microscopy. We observed significantly greater epithelial cell invasion by S. marcescens compared to … en_US
dc.publisher Taylor & Francis en_US
dc.title Serratia marcescens is injurious to intestinal epithelial cells en_US
dc.type Article en_US


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