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Serratia marcescens is injurious to intestinal epithelial cells

Show simple item record Ochieng, John B Boisen, Nadia Lindsay, Brianna Santiago, Araceli Ouma, Collins Ombok, Maurice Fields, Barry Stine, O Colin Nataro, James P 2018-01-22T12:27:23Z 2018-01-22T12:27:23Z 2014-11-02
dc.description.abstract Diarrhea causes substantial morbidity and mortality in children in low-income countries. Although numerous pathogens cause diarrhea, the etiology of many episodes remains unknown. Serratia marcescens is incriminated in hospital-associated infections, and HIV/AIDS associated diarrhea. We have recently found that Serratia spp. may be found more commonly in the stools of patients with diarrhea than in asymptomatic control children. We therefore investigated the possible enteric pathogenicity of S. marcescens in vitro employing a polarized human colonic epithelial cell (T84) monolayer. Infected monolayers were assayed for bacterial invasion, transepithelial electrical resistance (TEER), cytotoxicity, interleukin-8 (IL-8) release and morphological changes by scanning electron microscopy. We observed significantly greater epithelial cell invasion by S. marcescens compared to … en_US
dc.publisher Taylor & Francis en_US
dc.title Serratia marcescens is injurious to intestinal epithelial cells en_US
dc.type Article en_US

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