Show simple item record

dc.contributor.authorOchieng, John B
dc.contributor.authorBoisen, Nadia
dc.contributor.authorLindsay, Brianna
dc.contributor.authorSantiago, Araceli
dc.contributor.authorOuma, Collins
dc.contributor.authorOmbok, Maurice
dc.contributor.authorFields, Barry
dc.contributor.authorStine, O Colin
dc.contributor.authorNataro, James P
dc.description.abstractDiarrhea causes substantial morbidity and mortality in children in low-income countries. Although numerous pathogens cause diarrhea, the etiology of many episodes remains unknown. Serratia marcescens is incriminated in hospital-associated infections, and HIV/AIDS associated diarrhea. We have recently found that Serratia spp. may be found more commonly in the stools of patients with diarrhea than in asymptomatic control children. We therefore investigated the possible enteric pathogenicity of S. marcescens in vitro employing a polarized human colonic epithelial cell (T84) monolayer. Infected monolayers were assayed for bacterial invasion, transepithelial electrical resistance (TEER), cytotoxicity, interleukin-8 (IL-8) release and morphological changes by scanning electron microscopy. We observed significantly greater epithelial cell invasion by S. marcescens compared to …en_US
dc.publisherTaylor & Francisen_US
dc.titleSerratia marcescens is injurious to intestinal epithelial cellsen_US

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record