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dc.contributor.authorOchola, Lyticia A
dc.contributor.authorAyieko, Cyrus
dc.contributor.authorKisia, Lily
dc.contributor.authorNg'wena, G Magak
dc.contributor.authorShabani, Estela
dc.contributor.authorOuma, Collins
dc.contributor.authorJohn, Chandy C
dc.date.accessioned2018-01-22T12:09:59Z
dc.date.available2018-01-22T12:09:59Z
dc.date.issued2014-09-01
dc.identifier.urihttps://repository.maseno.ac.ke/handle/123456789/178
dc.description.abstractIndividuals naturally exposed to Plasmodium falciparum lose clinical immunity after a prolonged lack of exposure. P. falciparum antigen-specific cytokine responses have been associated with protection from clinical malaria, but the longevity of P. falciparum antigen-specific cytokine responses in the absence of exposure is not well characterized. A highland area of Kenya with low and unstable malaria transmission provided an opportunity to study this question. The levels of antigen-specific cytokines and chemokines associated in previous studies with protection from clinical malaria (gamma interferon [IFN-γ], interleukin- 10 [IL-10], and tumor necrosis factor alpha [TNF-α]), with increased risk of clinical malaria (IL- 6), or with pathogenesis of severe disease in malaria (IL-5 and RANTES) were assessed by cytometric bead assay in April 2008, October 2008, and April 2009 in 100 children and …en_US
dc.publisherAmerican Society for Microbiologyen_US
dc.titleChanges in antigen-specific cytokine and chemokine responses to Plasmodium falciparum antigens in a highland area of Kenya after a prolonged absence of malari...en_US
dc.typeArticleen_US


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