Maseno University Repository

Sickle cell trait is not associated with endemic Burkitt lymphoma: An ethnicity and malaria endemicity‐matched case–control study suggests factors controlling EBV...

Show simple item record

dc.contributor.author Mulama, David H
dc.contributor.author Bailey, Jeffrey A
dc.contributor.author Foley, Joslyn
dc.contributor.author Chelimo, Kiprotich
dc.contributor.author Ouma, Collins
dc.contributor.author Jura, Walter G
dc.contributor.author Otieno, Juliana
dc.contributor.author Vulule, John
dc.contributor.author Moormann, Ann M
dc.date.accessioned 2018-01-22T11:48:11Z
dc.date.available 2018-01-22T11:48:11Z
dc.date.issued 2014-02
dc.identifier.uri https://repository.maseno.ac.ke/handle/123456789/176
dc.description.abstract Endemic Burkitt lymphoma (eBL) is associated with Epstein–Barr virus (EBV) and Plasmodium falciparum coinfections. Malaria appears to dysregulate immunity that would otherwise control EBV, thereby contributing to eBL etiology. Juxtaposed to human genetic variants associated with protection from malaria, it has been hypothesized that such variants could decrease eBL susceptibility, historically referred to as “the protective hypothesis.” Past studies attempting to link sickle cell trait (HbAS), which is known to be protective against malaria, with protection from eBL were contradictory and underpowered. Therefore, using a case–control study design, we examined HbAS frequency in 306 Kenyan children diagnosed with eBL compared to 537 geographically defined and ethnically matched controls. We found 23.8% HbAS for eBL patients, which was not significantly different … en_US
dc.title Sickle cell trait is not associated with endemic Burkitt lymphoma: An ethnicity and malaria endemicity‐matched case–control study suggests factors controlling EBV... en_US
dc.type Article en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Maseno University Repository


Browse

My Account