Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area...
dc.contributor.author | Munde, Elly O | |
dc.contributor.author | Raballah, Evans | |
dc.contributor.author | Okeyo, Winnie A | |
dc.contributor.author | Ong’echa, John M | |
dc.contributor.author | Perkins, Douglas J | |
dc.contributor.author | Ouma, Collins | |
dc.date.accessioned | 2018-01-19T13:38:05Z | |
dc.date.available | 2018-01-19T13:38:05Z | |
dc.date.issued | 2017-04-20 | |
dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/155 | |
dc.description.abstract | Background Improved understanding of the molecular mechanisms involved in pediatric severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel therapeutics. Identification of host genetic susceptibility factors in immune regulatory genes offers an important tool for deciphering malaria pathogenesis. The IL-23/IL-17 immune pathway is important for both immunity and erythropoiesis via its effects through IL-23 receptors (IL-23R). However, the impact of IL-23R variants on SMA has not been fully elucidated. Methods Since variation within the coding region of IL-23R may influence the pathogenesis of SMA, the association between IL-23R rs1884444 (G/T), rs7530511 (C/T), and SMA (Hb< 6.0 g/dL) was examined in children (n= 369, aged 6–36 months) with P. falciparum malaria in a holoendemic P. falciparum transmission area. Results Logistic … | en_US |
dc.publisher | BioMed Central | en_US |
dc.title | Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area... | en_US |
dc.type | Article | en_US |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |