• Login
    • Login
    Advanced Search
    View Item 
    •   Maseno IR Home
    • Journal Articles
    • School of Biological and Physical Science
    • Department of Botany
    • View Item
    •   Maseno IR Home
    • Journal Articles
    • School of Biological and Physical Science
    • Department of Botany
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Isolation of a new β-carboline alkaloid from aerial parts of Triclisia sacleuxii and its antibacterial and cytotoxicity effects

    Thumbnail
    View/Open
    Isolation of a new carboline alkaloid from aerial parts of Triclisia sacleuxii and its antibacterial and cytotoxicity effects.pdf (941.0Kb)
    Publication Date
    2017-01-01
    Author
    Samita, F.
    O. Ochieng, C.
    Okinda Owuor, P.
    O.A. Manguro, L.
    O. Midiwo, J.
    Metadata
    Show full item record
    Abstract/Overview
    A new β-carboline alkaloid named sacleuximine A (1) together with known compounds palmatine (2), isotetrandrine (3), trans-Nferuloyltyramine (4), trans-N-caffeoyltyramine (5), yangambin (6), syringaresinol (7), sesamin (8), (+) epi-quercitol (9), 4-hydroxybenzaldehyde (10), β-sitosterol (11), quercetin 3-O-rutinoside (12) and myricetin 3-O-β-glucose (1→6) α-rhamnoside (13) have been isolated from methanol extract of Triclisia sacleuxii aerial parts. Compounds 1–10 were evaluated for their cytotoxicity against human adenocarcinoma (HeLa), human hepatocarcinoma (Hep3B) and human breast carcinoma (MCF-7) cells lines and also for antibacterial activities against both Gram-positive and Gram-negative bacteria. The cytotoxicity (IC50) values ranged between 0.15 and 36.7 μM while the minimum inhibitory concentrations were found to be in the range of 3.9 and 125 μM, respectively. This is the first report of antibacterial compounds and the isolation of lignans together with a β-carboline alkaloid from T. sacleuxii.
    Permalink
    https://repository.maseno.ac.ke/handle/123456789/1501
    Collections
    • Department of Botany [229]

    Maseno University. All rights reserved | Copyright © 2022 
    Contact Us | Send Feedback

     

     

    Browse

    All of Maseno IRCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Maseno University. All rights reserved | Copyright © 2022 
    Contact Us | Send Feedback