Abstract:
A new β-carboline alkaloid named sacleuximine A (1) together
with known compounds palmatine (2), isotetrandrine (3), trans-Nferuloyltyramine (4), trans-N-caffeoyltyramine (5), yangambin (6),
syringaresinol (7), sesamin (8), (+) epi-quercitol (9), 4-hydroxybenzaldehyde (10), β-sitosterol (11), quercetin 3-O-rutinoside (12) and myricetin 3-O-β-glucose (1→6) α-rhamnoside (13) have been isolated from
methanol extract of Triclisia sacleuxii aerial parts. Compounds 1–10
were evaluated for their cytotoxicity against human adenocarcinoma
(HeLa), human hepatocarcinoma (Hep3B) and human breast carcinoma (MCF-7) cells lines and also for antibacterial activities against
both Gram-positive and Gram-negative bacteria. The cytotoxicity
(IC50) values ranged between 0.15 and 36.7 μM while the minimum
inhibitory concentrations were found to be in the range of 3.9 and
125 μM, respectively. This is the first report of antibacterial compounds
and the isolation of lignans together with a β-carboline alkaloid from
T. sacleuxii.
