Browsing by Author "GA Awandare, C Ouma, CC Keller, T Were, R Otieno, Y Ouma, GC Davenport, JB Hittner, JM Ong'Echa, R Ferrell, DJ Perkins"
Now showing items 1-17 of 17
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(−7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
Okeyo, WA; Munde, EO; Okumu, W; Raballah, E; Anyona, SB; Vulule, JM; Ong’echa, JM; Perkins, DJ; Ouma, C (Bio Med Central, 2013)In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ... -
Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya.
Munde, EO; Okeyo, WA; Raballah, E; Anyona, SB; Were, T; Ong’echa, JM; Perkins, DJ; Ouma, C (BMC infectious diseases, 2017-04)BACKGROUND: Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG) antibodies and mediate phagocytosis of ... -
Bacteremia in Kenyan children presenting with malaria
Were, T; Davenport, GC; Hittner, JB; Ouma, C; Vulule, JM; Ong'echa, JM; Perkins, DJ (American Society for Microbiology, 2011-02-01)Since the etiologies and clinical outcomes of bacteremia in children with Plasmodium falciparum infections, particularly in areas of holoendemic malaria transmission, are largely unexplored, blood cultures and comprehensive ... -
Clinical predictors of severe malarial anaemia in a holoendemic Plasmodium falciparum transmission area.
Were; Novelli, Enrico M; Hittner, James B; Davenport, GC; Ouma, Collins; Obaro, Stephen; Kaplan, Sandra; Ong'echa, JM; Perkins, DJ (British Journal of Haematology, 2005)Severe malarial anaemia (SMA) is a common complication of Plasmodium falciparum infections, resulting in mortality rates that may exceed 30% in paediatric populations residing in holoendemic transmission areas. One ... -
Clinical Predictors of Severe Malarial Anemia in a Holoendemic P. Falciparum Transmission Area
Hittner, James B; Davenport, GC; Ouma, C; Were, T; Obaro, S; Kaplan, S; Ong'echa, JM; Perkins, DJ; Novelli, EM (2005)Severe malarial anaemia (SMA) is a common complication of Plasmodium falciparum infections, resulting in mortality rates that may exceed 30% in paediatric populations residing in holoendemic transmission areas. One ... -
Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children.
Ouma, C; Davenport, GC; Garcia, S; Kempaiah, P; Chaudhary, A; Were, T; Anyona, SB; Raballah, E; Konah, SN; Hittner, JB; Vulule., JM; Ong'echa, JM; Perkins, DJ (Pub Med Central, 2012-02)Development of protective immunity against Plasmodium falciparum is partially mediated through binding of malaria-specific IgG to Fc gamma (γ) receptors. Variation in human FcγRIIA-H/R-131 and FcγRIIIB-NA1/NA2 affect ... -
Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality
Anyona, SB; Kempaiah, P; Raballah, E; Ouma, C; Were, T; Davenport, GC; Konah, SN; Vulule, JM; Hittner, JB; Gichuki, CW; Ong'echa, JM; Perkins, DJ (Pub Med Central, 2011-12)Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children residing in regions where Plasmodium falciparum transmission is holoendemic. Although largely unexplored in children with SMA, ... -
Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.
T, Were,; CW, Gichuki; Ong'echa, JM; Ouma, Collins; Anyona, SB; Kempaiah, P; Raballah, E; Davenpor, GC; Konah, SN; Vulule, JM; Hittner, James B; Perkins, DJ (PubMed, 2012)Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children residing in regions where plasmodium falciparum transmission is holoendemic. Although largely unexplored in children with SMA, ... -
Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults
Were, T; Phawong, Chintana; Ouma, Collins; Tangteerawatana, Piyatida; Thongshoob, Jarinee; Mahakunkijcharoen, Yuvadee; Wattanasirichaigoon, Duangrurdee; Perkins, DJ; Khusmith, Srisin (Immunogenetics, 2012)Polymorphic variability in immune response genes, such as IL12B, encoding the IL-12p40 subunit is associated with susceptibility to severe malaria in African populations. Since the role of genetic variation in conditioning ... -
Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria
Were, T; Otieno, Richard O; Ouma, Collins; Ong'echa, JM; Kelle, Christopher C; Waindi, Eliud N; Michaels, Marian G; Day, Richard D; Vulule, John M; Perkins, DJ (AIDS, 2005)Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria -
Parasitemia, anemia, and malarial anemia in infants and young children in a rural holoendemic Plasmodium falciparum transmission area.
Were, T; Ong'echa, JM; Keller, CC; Ouma, C; Otieno, Richard O; Lewis, Z L; Ochie, D; Slingluff, JL; Mogere, S; Ogonji, GA; Orago, AS; Vulule, JM; Kaplan, SS; Day, RD; Perkins, DJ (American Journal of Tropical Medicine and Hygiene, 2005)Malarial anemia (MA) is a multifactorial disease for which the complex etiological basis is only partially defined. The association of clinical, nutritional, demographic, and socioeconomic factors with parasitemia, ... -
Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria
Ong'echa, JM; Raballah, EO; Kempaiah, PM; Anyona, SB; Were, T; Davenport, GC; Konah, S; Vulule, JM; Ouma, C; Hittner, JB; Perkins, DJ (Pub Med Central, 2011-08)BACKGROUND: Plasmodium falciparum malaria remains a leading cause of morbidity and mortality among African children. Innate immunity provides the first line of defence against P. falciparum infections, particularly in young ... -
Polymorphic Variability in the 3'Untranslated Region (UTR) of IL12B is associated with Susceptibility to Severe Anaemia in Kenyan Children with Acute Plasmodium...
Raballah; Ong'echa, JM; Kempaiah, PM; Anyona, SB; Were, T; Davenport, GC; Konah, S; Vulule, JM; Ouma, C; Hittner, James B; Perkins, DJ (BioMed Central, 2005)Plasmodium falciparum malaria remains a leading cause of morbidity and mortality among African children. Innate immunity provides the first line of defence against P. falciparum infections, particularly in young children ... -
Polymorphic Variability in the Interleukin (IL)-1Beta Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL-1Beta Production
Otieno, Micheal F; Ouma, C; Davenport, GC; Awandare, GA; Keller, CC; Were, T; Vulule, JM; Martinson, J; Ong'echa, JM; Ferrell, RE; Perkins, DJ (PubMed, 2012)Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe ... -
Reduced interferon (IFN)-α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality
Kempaiah, P; Anyona, SB; Raballah, E; Davenport, GC; Were, T; Hittner, JB; Ong'echa JM, JM; Perkins, DJ (Pub Med Central, 2012-08)Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ... -
Reduced Systemic Bicyclo-Prostaglandin-E2 and Cyclooxygenase-2 Gene Expression are Associated with Inefficient Erythropoiesis and Enhanced Uptake of Monocytic Hemozoin in Children with Severe Malarial Anemia
Anyona, SB; Kempaiah, P; Raballah, E; Davenport, GC; Were, T; Konah, SN; Vulule, JM; Hittner, JB; Gichuki, CW; Ong’echa, JM; Perkins, DJ (Pub Med Central, 2012-08)In holoendemic Plasmodium falciparum transmission areas, severe malaria primarily occurs in children <48 mos. and manifests as severe malarial anemia [SMA; hemoglobin (Hb)<6.0 g/dL]. Induction of high levels of prostaglandin-E2 ... -
Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia.
Anyona, SB; Kempaiah, P; Davenport, GC; Vulule, JM; Hittner, JB; Ong’echa, JM; Perkins, DJ (Biochemical and biophysical research communications, 2013)In holoendemic Plasmodium falciparum transmission regions, malarial anemia is a leading cause of childhood morbidity and mortality. Identifying biomarkers of malaria disease severity is important for identifying at-risk ...