Browsing by Author "Ouma, C"
Now showing items 1-16 of 16
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(−7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
Okeyo, WA; Munde, EO; Okumu, W; Raballah, E; Anyona, SB; Vulule, JM; Ong’echa, JM; Perkins, DJ; Ouma, C (Bio Med Central, 2013)In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ... -
Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya.
Munde, EO; Okeyo, WA; Raballah, E; Anyona, SB; Were, T; Ong’echa, JM; Perkins, DJ; Ouma, C (BMC infectious diseases, 2017-04)BACKGROUND: Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG) antibodies and mediate phagocytosis of ... -
Bacteremia in Kenyan children presenting with malaria
Were, T; Davenport, GC; Hittner, JB; Ouma, C; Vulule, JM; Ong'echa, JM; Perkins, DJ (American Society for Microbiology, 2011-02-01)Since the etiologies and clinical outcomes of bacteremia in children with Plasmodium falciparum infections, particularly in areas of holoendemic malaria transmission, are largely unexplored, blood cultures and comprehensive ... -
Clinical Predictors of Severe Malarial Anemia in a Holoendemic P. Falciparum Transmission Area
Hittner, James B; Davenport, GC; Ouma, C; Were, T; Obaro, S; Kaplan, S; Ong'echa, JM; Perkins, DJ; Novelli, EM (2005)Severe malarial anaemia (SMA) is a common complication of Plasmodium falciparum infections, resulting in mortality rates that may exceed 30% in paediatric populations residing in holoendemic transmission areas. One ... -
Comparison of Amplicor HIV-1 DNA Test version 1.5 and Cobas AmpliPrep/Cobas TaqMan HIV-1 Qual test PCR assays for the diagnosis of HIV among HIV expose...
Makwaga, O; Ouma, C; Muigai, A; Andayi, F; Mokaya, T; Mwau, M (2015)In Kenya PCR solutions are available for HIV diagnosis. However few studies have evaluated existing HIV diagnosis and determined the prevalence of HIV infection in infants resident in disease endemic regions of western ... -
Correlates of Behavior Management Strategies Among Learners With Autistic Spectrum Disorders In Primary Schools In Western Kenya
Khasakhala, E; Oracha, P; Ouma, C; Macharia, S (2014)Practitioners handling learners with Autistic Spectrum Disorders (ASDs) often feel ill- prepared to effectively manage this disorder. Quite often, when faced with cases of challenging behaviour, teachers use coping ... -
Factors associated with non-adherence to Artemisinin-based combination therapy (ACT) to malaria in a rural population from holoendemic region of western Kenya.
Onyango, EO; Ayodo, G; Watsierah, CA; Were, T; Okumu, W; Anyona, SB; Raballah, E; Okoth, JM; Gumo, S; Orinda, GO; Ouma, C (Pub Med Central, 2012-06)Background Over the years, reports implicate improper anti-malarial use as a major contributor of morbidity and mortality amongst millions of residents in malaria endemic areas, Kenya included. However, there are limited ... -
Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children.
Ouma, C; Davenport, GC; Garcia, S; Kempaiah, P; Chaudhary, A; Were, T; Anyona, SB; Raballah, E; Konah, SN; Hittner, JB; Vulule., JM; Ong'echa, JM; Perkins, DJ (Pub Med Central, 2012-02)Development of protective immunity against Plasmodium falciparum is partially mediated through binding of malaria-specific IgG to Fc gamma (γ) receptors. Variation in human FcγRIIA-H/R-131 and FcγRIIIB-NA1/NA2 affect ... -
Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality
Anyona, SB; Kempaiah, P; Raballah, E; Ouma, C; Were, T; Davenport, GC; Konah, SN; Vulule, JM; Hittner, JB; Gichuki, CW; Ong'echa, JM; Perkins, DJ (Pub Med Central, 2011-12)Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children residing in regions where Plasmodium falciparum transmission is holoendemic. Although largely unexplored in children with SMA, ... -
MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia
Were, T; Awandare, GA; Martinson, JJ; Ouma, C; Davenport, GC; Ong'echa, JM; Wang, W; L, Leng; RE, Ferrell,; R, Bucala,; DJ, Perkins (Journal of Infectious Diseases, 2012)Severe malarial anemia (SMA) resulting from Plasmodium falciparum infection is one of the leading causes of childhood mortality in sub-Saharan Africa. The innate immune mediator macrophage migration inhibitory factor ... -
A Model on the Impact of Treating Typhoid with Anti-malarial: Dynamics of Malaria Concurrent and Co-infection with Typhoid
Akinyi, Okaka C; Mugisha, JYT; Manyonge, A; Ouma, C; Maseno, Kenya (2015)International Journal of Mathematical Analysis Vol. 9, 2015, no. 11, 541 - 551 HIKARI Ltd, www.m-hikari.com http://dx.doi.org/10.12988/ijma.2015.412403 … A Model on the Impact of Treating Typhoid with … Department ... -
Modelling the Impact of Misdiagnosis and Treatment on the Dynamics of Malaria Concurrent and Co-infection with Pneumonia
Akinyi, Okaka; Mugisha, JYT; Manyonge, A; Ouma, C; Maseno, Kenya (2013)Incidences of misdiagnosis of diseases with similar symptoms as malaria has increased lately due to the increasing levels of endemicity of these diseases and their co- infection with malaria. In this paper a mathematical ... -
Parasitemia, anemia, and malarial anemia in infants and young children in a rural holoendemic Plasmodium falciparum transmission area.
Were, T; Ong'echa, JM; Keller, CC; Ouma, C; Otieno, Richard O; Lewis, Z L; Ochie, D; Slingluff, JL; Mogere, S; Ogonji, GA; Orago, AS; Vulule, JM; Kaplan, SS; Day, RD; Perkins, DJ (American Journal of Tropical Medicine and Hygiene, 2005)Malarial anemia (MA) is a multifactorial disease for which the complex etiological basis is only partially defined. The association of clinical, nutritional, demographic, and socioeconomic factors with parasitemia, ... -
Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria
Ong'echa, JM; Raballah, EO; Kempaiah, PM; Anyona, SB; Were, T; Davenport, GC; Konah, S; Vulule, JM; Ouma, C; Hittner, JB; Perkins, DJ (Pub Med Central, 2011-08)BACKGROUND: Plasmodium falciparum malaria remains a leading cause of morbidity and mortality among African children. Innate immunity provides the first line of defence against P. falciparum infections, particularly in young ... -
Polymorphic Variability in the 3'Untranslated Region (UTR) of IL12B is associated with Susceptibility to Severe Anaemia in Kenyan Children with Acute Plasmodium...
Raballah; Ong'echa, JM; Kempaiah, PM; Anyona, SB; Were, T; Davenport, GC; Konah, S; Vulule, JM; Ouma, C; Hittner, James B; Perkins, DJ (BioMed Central, 2005)Plasmodium falciparum malaria remains a leading cause of morbidity and mortality among African children. Innate immunity provides the first line of defence against P. falciparum infections, particularly in young children ... -
Polymorphic Variability in the Interleukin (IL)-1Beta Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL-1Beta Production
Otieno, Micheal F; Ouma, C; Davenport, GC; Awandare, GA; Keller, CC; Were, T; Vulule, JM; Martinson, J; Ong'echa, JM; Ferrell, RE; Perkins, DJ (PubMed, 2012)Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe ...