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Polymorphic Variability in the Interleukin (IL)-1Beta Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL-1Beta Production

Otieno, Micheal F; Ouma, C; Davenport, GC; Awandare, GA; Keller, CC; Were, T; Vulule, JM; Martinson, J; Ong'echa, JM; Ferrell, RE; Perkins, DJ (PubMed, 2012)

Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe ...

MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia

Were, T; Awandare, GA; Martinson, JJ; Ouma, C; Davenport, GC; Ong'echa, JM; Wang, W; L, Leng; RE, Ferrell,; R, Bucala,; DJ, Perkins (Journal of Infectious Diseases, 2012)

Severe malarial anemia (SMA) resulting from Plasmodium falciparum infection is one of the leading causes of childhood mortality in sub-Saharan Africa. The innate immune mediator macrophage migration inhibitory factor ...