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Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.
(PubMed, 2012)
Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children
residing in regions where plasmodium falciparum transmission is holoendemic. Although
largely unexplored in children with SMA, ...
Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults
(Immunogenetics, 2012)
Polymorphic variability in immune response genes, such as IL12B, encoding the IL-12p40
subunit is associated with susceptibility to severe malaria in African populations. Since the
role of genetic variation in conditioning ...