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Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya

Munde, Elly O; Okeyo, Winnie A; Raballah, Evans; Anyona, Samuel B; Were, Tom; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (BioMed Central, 2017-04-20)

Background Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG) antibodies and mediate phagocytosis of ...

Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area...

Munde, Elly O; Raballah, Evans; Okeyo, Winnie A; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (BioMed Central, 2017-04-20)

Background Improved understanding of the molecular mechanisms involved in pediatric severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel therapeutics. Identification of host genetic ...

Functional Haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children

Ouma, Collins; Davenport, Gregory C; Garcia, Steven; Kempaiah, Prakasha; Chaudhary, Ateefa; Were, Tom; Anyona, Samuel B; Raballah, Evans; Konah, Stephen N; Hittner, James B; Vulule, John M; Ong’echa, John M; Perkins, Douglas J (Springer-Verlag, 2012-02-01)

Development of protective immunity against Plasmodium falciparum is partially mediated through binding of malaria-specific IgG to Fc gamma (γ) receptors. Variations in human FcγRIIA-H/R-131 and FcγRIIIB-NA1/NA2 affect ...

Knowledge and behaviour as determinants of anti-malarial drug use in a peri-urban population from malaria holoendemic region of western Kenya

Watsierah, Carren A; Jura, Walter G; Raballah, Evans; Kaseje, Dan; Abong'o, Benard; Ouma, Collins (BioMed Central, 2011-04-20)

The appropriate use of anti-malarial drugs determines therapeutic efficacy and the emergence and spread of drug-resistant malaria. Strategies for improving drug compliance require accurate information about current ...

Communicating African spirituality through ecology: Challenges and prospects for the 21st century

Gumo, Sussy; Gisege, Simon O; Raballah, Evans; Ouma, Collins (2012-06-19)

This review was set in the context of African spirituality and ecology. Specifically, the review addressed issues of African spirituality and the environment from a Kenyan context. Through analyses on existing literature, ...

Polymorphisms in Fc gamma receptor (FcγRIIIA-176 F/V) and Toll-like receptor (TLR9 [-1237 T/C]) are associated with protection against severe malarial anemia an...

Munde, Elly O; Okeyo, Winnie A; Anyona, Samwel B; Raballah, Evans; Konah, Stephen; Okumu, Wilson; Ogonda, Lilian; Vulule, John; Ouma, Collins (American Society for Microbiology, 2012-10-08)

Understanding the immunogenetic basis of naturally acquired immunity to Plasmodium falciparum infection would aid in designing a rationally-based malaria vaccine. Variants within the Fc gamma receptors (FcγRs) mediate ...

(− 7402 T/G and-4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels

Okeyo, Winnie A; Munde, Elly O; Okumu, Wilson; Raballah, Evans; Anyona, Samuel B; Vulule, John M; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (Bio Med Central, 2013)

In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb)< 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ...