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Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya
(BioMed Central, 2017-04-20)
Background Naturally-acquired immunity to Plasmodium falciparum malaria develops after
several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG)
antibodies and mediate phagocytosis of ...
HIV-1 protease inhibitor drug resistance in Kenyan antiretroviral treatment-naive and-experienced injection drug users and non-drug users
(BioMed Central, 2015-08-15)
Background Although injection drug use drives antiretroviral drug resistance, the prevalence
of protease inhibitor (PI) resistance among Kenyan IDUs remains undetermined. We,
therefore, explored PI resistance mutations ...
HIV-1 protease inhibitor drug resistance in Kenyan antiretroviral treatment-naive and-experienced injection drug users and non-drug users
(BioMed Central, 2015-08-11)
Background Although injection drug use drives antiretroviral drug resistance, the prevalence
of protease inhibitor (PI) resistance among Kenyan IDUs remains undetermined. We,
therefore, explored PI resistance mutations ...
Hepatitis B virus sero-profiles and genotypes in HIV-1 infected and uninfected injection and Non-injection drug users from coastal Kenya
(BioMed Central, 2015-07-30)
Background Information about HBV sero-markers, infection stages and genotypes in HIV-1
infected and uninfected injection and non-injection drug users (IDUs) in Kenya remains
elusive. Methods A cross-sectional study ...
Clinical chemistry profiles in injection heroin users from Coastal Region, Kenya
(Biomed central, 2014-07-09)
Background Although the co-burden of injection drug use and HIV is increasing in Africa,
little is known about the laboratory markers of injection drug use and anti-retroviral treatment
(ART) in Kenyan injection drug ...
Functional Haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children
(Springer-Verlag, 2012-02-01)
Development of protective immunity against Plasmodium falciparum is partially
mediated through binding of malaria-specific IgG to Fc gamma (γ) receptors. Variations in
human FcγRIIA-H/R-131 and FcγRIIIB-NA1/NA2 affect ...
Polymorphic variability in the 3'untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falc...
(BioMed Central, 2011-08-06)
Plasmodium falciparum malaria remains a leading cause of morbidity and
mortality among African children. Innate immunity provides the first line of defence against P.
falciparum infections, particularly in young children ...
Natural monocytic acquisition of haemozoin and rantes polymorphisms: association with malarial disease outcomes and functional changes in children from Wester...
(2011-08-15)
Plasmodium falciparum is an important cause of morbidity and mortality in children residing
in holoendemic transmission areas largely from severe malarial anaemia (SMA). Although
overproduction of inflammatory-derived ...