An investigative study of dwarf mango (Boribo Muyini) seed kernel extract against inflammatory agent Staphylococcus aureus

Abstract

Alternative herbal medicine has been used to treat various infections from centuries. Natural plants contain Phyto constituents having similar chemical properties as of synthetic antibiotics. Boribo Muyini a typical Tanzanian dwarf breed of Mangifera indica have been reported for various medicinal effects like antioxidant, antimicrobial, antihelminthic, antidiabetic and antiallergic etc. Staphylococcus aureus belongs to eubacteria group, facultative anaerobic invasive bacterium is a highly evaluated in inducing inflammation in human and highly resistant to antibiotics. Due to its antibiotics resistance, it became vital to evaluate biological properties of medicinal plants in tropical regions. This study was aimed to evaluate the antimicrobial activity of seed kernel on Staphylococcus aureus isolated from wound infected patient and diarrhea patient. Cold methanolic extraction was performed to extract bioactive compound from seed kernel. Disk diffusion method was used to assess the antibacterial nature of the extract which where compared with the standard antibiotic vancomycin. Discs prepared in 400µg concentration of methanolic extract of seed kennel was effective against Staphylococcus aureus by giving an inhibition zone of 19 mm when compared to standard vancomycin antibiotic disc (30 µg) which gave an inhibition zone of 20mm