| dc.contributor.author | Rahab W Kamau, Veronica M Masila, Jacob O Midiwo, Quintino A Mgani, Mallika Kumarihamy, Mei Wang, Jianping Zhao, Ilias Muhammad | |
| dc.date.accessioned | 2022-06-22T09:19:03Z | |
| dc.date.available | 2022-06-22T09:19:03Z | |
| dc.date.issued | 2022 | |
| dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/5288 | |
| dc.description | To link to this article: https://doi.org/10.1080/14786419.2022.2062349 | en_US |
| dc.description.abstract | A new 3,800-flavanone-flavonol dimer gnidiflavanone-flavonol (1)
and 10 known compounds (2–11), including four rare primula type flavones 2–5, were isolated from the roots of Gnidia apicu lata. Compounds 2–5 and 7 were reported for the first time from
the plant family Thymelaeceae. Structures of the isolated com pounds were established by spectroscopic data, including 1D and
2D NMR (COSY, HMBC, HSQC and ROESY) and mass spectrometry,
as well as by the comparison with literature data. The crude roots
extract and isolated compounds were evaluated for antimicrobial
and antiplasmodial activities. Among isolated compounds, 6-
hydroxyflavone (4) and 6-O-acetylflavone (4a) showed antiplasmo dial activity against chloroquine-sensitive (D6) and chloroquine resistant (W2) strains of Plasmodium falciparum | en_US |
| dc.publisher | Taylor & Francis | en_US |
| dc.subject | Gnidia apiculata; 3,800- flavanone-flavonol dimer; gnidiflavanone-flavonol; primula-type flavones; antiplasmodial | en_US |
| dc.title | A new gnidiflavanone-flavonol dimer and other constituents from Gnidia apiculata | en_US |
| dc.type | Article | en_US |
