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dc.contributor.authorVeronica M Masila, Albert J Ndakala, Jacob O Midiwo, Robert Byamukama, Rahab W Kamau, Mallika Kumarihamy, Ilias Muhammad
dc.date.accessioned2022-06-22T09:09:11Z
dc.date.available2022-06-22T09:09:11Z
dc.date.issued2022-05-03
dc.identifier.urihttps://repository.maseno.ac.ke/handle/123456789/5287
dc.descriptionTo link to this article: https://doi.org/10.1080/14786419.2020.1833201en_US
dc.description.abstractMonoterpene derivatives are of great biological relevance in the pharmaceutical industry. In the present study, pyrrolidine deriva tive of a carvotacetone, 3-O-benzylcarvotacetone (1), and selected monoterpenes (3-hydroxy-2-isopropyl-5-methyl-p-benzoquinone (3) and cis-piperitol (5)) were prepared to provide (R)-1-(4-(benzy loxy)-5-isopropyl-2-methylcyclohexa-1,3-dien-1-yl)-pyrrolidine (2), 2-isopropyl-5-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl acetate (4), cis-3-hydroxypiperitone (6) and carvacrol (7). Structure of 2 was determined based on NMR and HRMS spectral data. Compound 4 exhibited activity against fungi Cryptococcus neoformans with an IC50 value of < 0.8 mg/mL. In addition, this compound 4 had an IC50 value of 14.97 mg/mL against methicillin resistant Staphylococcus aureus bacteria. Previous to the current study, both compound 6 and 7 had been reported to have anti-micro bial and anti-fungal activitiesen_US
dc.publisherTaylor & Francisen_US
dc.subjectMonoterpenes; 2-Isopropyl 5-methyl-3,6-dioxocyclo hexa-1,4-dien-1-yl acetate; Carvacrol; Cis-3- hydroxypiperitone; Anti MRSA; Anti-cryptococcen_US
dc.titleSynthesis of a pyrrolidine derivative of a carvotacetone and monoterpenes for anti-methicillin-resistant Staphylococcus aureus and anti-cryptococcal propertiesen_US
dc.typeArticleen_US


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