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dc.contributor.authorDorothy A Okoth, Joachim J Hug, Ronald Garcia, Cathrin Spröer, Jörg Overmann, Rolf Müller
dc.date.accessioned2021-05-19T12:36:47Z
dc.date.available2021-05-19T12:36:47Z
dc.date.issued2020
dc.identifier.urihttps://repository.maseno.ac.ke/handle/123456789/3765
dc.description.abstractMyxobacteria represent an under-investigated source for biologically active natural products featuring intriguing structural moieties with potential applications, e.g., in the pharmaceutical industry. Sorangiadenosine and the here-discovered 2-hydroxysorangiadenosine are myxobacterial sesquiterpene–nucleosides with an unusual structural moiety, a bicyclic eudesmane-type sesquiterpene. As the biosynthesis of these rare terpene–nucleoside hybrid natural products remains elusive, we investigated secondary metabolomes and genomes of several 2-hydroxysorangiadenosine-producing myxobacteria. We report the isolation and full structure elucidation of 2-hydroxysorangiadenosine and its cytotoxic and antibiotic activities and propose a biosynthetic pathway in the myxobacterium Vitiosangium cumulatum MCy10943en_US
dc.publisherMultidisciplinary Digital Publishing Instituteen_US
dc.subjectmyxobacteria; terpene–nucleoside; biosynthesis; antibiotics; sorangiadenosine; 2-hydroxysorangiadenosine; secondary metabolites; genome-mining; antibiotics; natural products discoveryen_US
dc.title2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene–Nucleosideen_US
dc.typeArticleen_US


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