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Antioxidant activities oftriacontanyl-E-cinnamoatesmetabolites from Caesalpinia volkensii root bark extracts

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dc.contributor.author Charles O Ochieng, Atul Shrivastava, Upma Chaturvedi, Ashok K Khanna, P Okinda, Lawrence AO Owuor, Rakesh K Asthana
dc.date.accessioned 2020-11-24T08:04:36Z
dc.date.available 2020-11-24T08:04:36Z
dc.date.issued 2017
dc.identifier.uri https://repository.maseno.ac.ke/handle/123456789/2935
dc.description.abstract Natural antioxidants have been reported to prevent oxidative damage caused by free radicals generated during biochemical processes and thus useful in prevention of several degenerative diseases. The present study evaluated the antioxidant value of Caesalpinia volkensii Harms (Leguminosae) root bark that is reported to have several ethno-medicinal applications. In-vitrofree radical scavenging and inhibition bioassays guided chromatographic separation carriedout on the root bark extracts resulted into isolation of three cinnamic acid esters, namely triacontanyl-E-ferulate (1), tricontanyl-(E)-caffaete (2) and 30΄-hydroxytriacontanyl-(E)-ferulate (3) were isolated, along with caesaldekarin C (4) and 5-hydroxyvinhaticoic acid (5) from the potent antioxidant ethyl acetate extract. The compounds were identified using spectroscopic techniques. Compounds 1, 2and 3exhibited significant (p≤0.05) inhibition of free radical generation in xanthine oxidase systems, scavenging of superoxide anion (O2 .−), inhibition of hydroxyl radical (•OH) and inhibition of microsomal lipid peroxidation with comparable LC50 to those of respective reference standards. This is the first report on antioxidant principles from C. volkensii and the result thus support in part the folklore use of the plant root bark to manage human ailments. en_US
dc.publisher Research gate en_US
dc.subject Caesalpiniodeae; Caesalpinia volkensii; Antioxidants; triacontanyl-E-ferrulate; 30΄-hydroxytricontanyl-(E)-ferrulate. en_US
dc.title Antioxidant activities oftriacontanyl-E-cinnamoatesmetabolites from Caesalpinia volkensii root bark extracts en_US
dc.type Article en_US


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