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Isolation of a new β-carboline alkaloid from aerial parts of Triclisia sacleuxii and its antibacterial and cytotoxicity effects

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dc.contributor.author Fidelis Samita, Charles Otieno Ochieng, Philip Okinda Owuor, Lawrence Onyango Arot Manguro, Jacob Ogweno Midiwo
dc.date.accessioned 2020-11-24T08:00:13Z
dc.date.available 2020-11-24T08:00:13Z
dc.date.issued 2017-03-04
dc.identifier.uri https://repository.maseno.ac.ke/handle/123456789/2933
dc.description.abstract A new β-carboline alkaloid named sacleuximine A (1) together with known compounds palmatine (2), isotetrandrine (3), trans-Nferuloyltyramine (4), trans-N-caffeoyltyramine (5), yangambin (6), syringaresinol (7), sesamin (8), (+) epi-quercitol (9), 4-hydroxybenzaldehyde (10), β-sitosterol (11), quercetin 3-O-rutinoside (12) and myricetin 3-O-β-glucose (1→6) α-rhamnoside (13) have been isolated from methanol extract of Triclisia sacleuxii aerial parts. Compounds 1–10 were evaluated for their cytotoxicity against human adenocarcinoma (HeLa), human hepatocarcinoma (Hep3B) and human breast carcinoma (MCF-7) cells lines and also for antibacterial activities against both Gram-positive and Gram-negative bacteria. The cytotoxicity (IC50) values ranged between 0.15 and 36.7 μM while the minimum inhibitory concentrations were found to be in the range of 3.9 and 125 μM, respectively. This is the first report of antibacterial compounds and the isolation of lignans together with a β-carboline alkaloid from T. sacleuxii. en_US
dc.publisher Taylor & Francis en_US
dc.subject Triclisia sacleuxii; Menispermaceae; secondary metabolites; cytotoxicity; antibacterial; aerial parts en_US
dc.title Isolation of a new β-carboline alkaloid from aerial parts of Triclisia sacleuxii and its antibacterial and cytotoxicity effects en_US
dc.type Article en_US


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