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dc.contributor.authorCharles O Ochieng, Daniel W Nyongesa, Kevin O Yamo, Joab O Onyango, Moses K Langat, Lawrence AO Manguro
dc.date.accessioned2020-11-24T07:42:04Z
dc.date.available2020-11-24T07:42:04Z
dc.date.issued2020-10-01
dc.identifier.urihttps://repository.maseno.ac.ke/handle/123456789/2930
dc.descriptionThe record of this article can be found on this URL. https://doi.org/10.1016/j.fitote.2020.104719en_US
dc.description.abstractA systematic analysis of the root bark of Zanthoxylum chalybeum was conducted to establish the antidiabetic potential of isolated compounds based on its ethnomedicinal use to manage diabetes. Chromatographic separation of alkaloid extracts led to isolation of three undescribed amides, chaylbemide A (1), chalybemide B (2) and chalybemide C (3) alongside the known fagaramide (4); four known benzophenanthridine alkaloids skimmianine (5), norchelerythrine (6), 6-acetonyldihydrochelerythrine (7) and 6-hydroxy-N-methyl decarine (8). The alkaloid free extracts yielded three known lignans, ailanthoidol (9), 2,3-epoxy-6,7-methylenedioxy coniferyl alcohol (10), sesamine (11), together with five known triterpenoids, lupeol (12), lupanone (13), 3α,20-dihydroxy-28-lupanoic acid (14), 20-hydroxy-3-oxo-28-lupanoic acid (15) and 3α,20,28-trihydroxylupane (16). The structures of the compounds were establisheden_US
dc.publisherElsevieren_US
dc.subjectZanthoxylum chalybeumAmide alkaloidsα-Amylase and α-glucosidase inhibitorsen_US
dc.titleα-Amylase and α-glucosidase inhibitors from Zanthoxylum chalybeum Engl. root barken_US
dc.typeArticleen_US


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