| dc.contributor.author | Tom Were, James B Hittner, Collins Ouma, Richard O Otieno, AS Orago, John M Ong'echa, John M Vulule, Christopher C Keller, Douglas J Perkins | |
| dc.date.accessioned | 2020-11-19T07:08:10Z | |
| dc.date.available | 2020-11-19T07:08:10Z | |
| dc.date.issued | 2006 | |
| dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/2854 | |
| dc.description.abstract | Severe malarial anemia (MA) is the primary manifestation of severe malaria among
children in areas of holoendemic Plasmodium falciparum transmission. Although overproduction of inflammatory-derived cytokines are implicated in the immunopathogenesis of severe MA, chemokines such as regulated on activation, normal T-cell expressed
and secreted (RANTES, CCL5) are largely unexplored in childhood malaria. We found
that RANTES is decreased during severe MA (p<0.01), and associated with suppression of erythropoiesis (p<0.05) and malaria-induced thrombocytopenia (p<0.05).
These findings suggest that thrombocytopenia may be a source of reduced RANTES
which may contribute, at least in part, to suppression of erythropoiesis in children with
malarial anemia. | en_US |
| dc.publisher | Haematologica | en_US |
| dc.subject | RANTES, malaria, anemia, erythropoiesis, reticulocyte production index, thrombocytopenia. | en_US |
| dc.title | Suppression of RANTES in children with Plasmodium falciparum malaria | en_US |
| dc.type | Article | en_US |
