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Microgeographic variations in Burkitt's lymphoma incidence correlate with differences in malnutrition, malaria and Epstein–Barr virus

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dc.contributor.author PO Sumba, EW Kabiru, E Namuyenga, N Fiore, RO Otieno, ..
dc.date.accessioned 2020-11-19T05:50:32Z
dc.date.available 2020-11-19T05:50:32Z
dc.date.issued 2010
dc.identifier.uri https://repository.maseno.ac.ke/handle/123456789/2839
dc.description.abstract Background: Endemic Burkitt's lymphoma (eBL) has been associated with Epstein–Barr virus (EBV) and holoendemic Plasmodium falciparum malaria. But recent evidence suggests that other risk factors are involved. Methods: We hypothesised that selenoprotein glutathione peroxidase (GPx), a surrogate of nutritional status, is an important biomarker for eBL risk. We measured plasma GPx, anthropometric markers of malnutrition, EBV viral loads and malaria parasitaemia in children aged 1–9 years (n=258) from two locations in Nyanza Province, Kenya, with higher-than-expected and lower-than-expected incidence of eBL. The study participants were malaria asymptomatic children from the community. Results: Children from eBL high-incidence areas had significantly lower GPx levels, high EBV viral load and more evidence of chronic malnutrition than children from eBL low-incidence areas (all P<0.001). Additionally, GPx levels were significantly lower in children with the highest EBV viral load and for those with P. falciparum infections (P=0.035 and P=0.004, respectively). Conclusions: These results suggest that selenium deficiency may be a risk factor for eBL. Main en_US
dc.publisher British journal of cancer 103 en_US
dc.subject selenium deficiency; Epstein – Barr virus (EBV); malaria; endemic Burkitt’s lymphoma; pediatric cancer; malnutrition en_US
dc.title Microgeographic variations in Burkitt's lymphoma incidence correlate with differences in malnutrition, malaria and Epstein–Barr virus en_US
dc.type Article en_US


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