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dc.contributor.authorCharles O Ochieng, J Ogweno Midiwo, P Okinda Owuor
dc.date.accessioned2020-07-29T11:53:22Z
dc.date.available2020-07-29T11:53:22Z
dc.date.issued2010
dc.identifier.urihttps://repository.maseno.ac.ke/handle/123456789/1711
dc.description.abstractVarious parts of Gardenia ternifolia (leaves, roots and stem bark) have been reported by traditional healers as a remedy against malaria fever. The aerial parts are coated with shiny materials rich in flavonoid aglycones. The crude acetone wash of the aerial parts showed anti-plasmodial activity of IC50 values 1.06 and 0.94 μg mL-1 against chloroquine-resistant (W2) and chloroquine-sensitive (D6) strains of Plasmodium falciparum, respectively. Bioassay guided chromatographic separation of the crude extracts afforded five flavonoids; (naringenin-7-O-methylether, quercetin-4, 7-O-dimethylether, kaempferol-7-O-methylether, 4, 5-Dihydroxy-6, 7-dimethoxyflavanone, naringenin-4, 7-O-dimethyl-ether) and two steroids; (stigmasterol, β-sitosterol). The same crude acetone surface extract as well as the pure isolates showed moderate larvicidal effects against 2nd instar Ae. aegypti larvae. Naringenin-7-O-methyl-ether was the most potent principle.en_US
dc.publisherUniversity of Nairobien_US
dc.subjectGardenia ternifolia; malaria feveren_US
dc.titleAnti-plasmodial and larvicidal effects of surface exudates of Gardenia ternifolia aerial partsen_US
dc.typeArticleen_US


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