| dc.contributor.author | Angeline Atieno Ochung, Lawrence Arot Oyango Manguro, Phillip Okinda Owuor, Isaac Ogoche Jondiko, Regina Achieng’Nyunja, Hosea Akala, Pauline Mwinzi, Sylvia Awino Opiyo | |
| dc.date.accessioned | 2020-07-16T12:02:08Z | |
| dc.date.available | 2020-07-16T12:02:08Z | |
| dc.date.issued | 2015-12-01 | |
| dc.identifier.uri | https://repository.maseno.ac.ke/handle/123456789/1508 | |
| dc.description.abstract | Phytochemical and biological evaluation of the stem bark of Alysicarpus ovalifolius led to the
isolation of three carbazole alkaloids identified as mohanimbine (1), koenimbine (2) and
koenidine (3) along with quercetin 3-O-glucoside (4), kaempferol 7-O-glucoside (5), orientin (6),
apigenin (7), quercetin (8), plumbagin (9) and stigmasterol (10). The structures of these
compounds were elucidated using physical and spectroscopic methods as well as comparison
with the literature data. Compound 3 showed strong activity against chloroquine-sensitive strain
I (D6) and the multi-drug resistant Indochicha I (W2) of Plasmodium falciparum with IC50
values of 63.07 ± 0.01 and 54.19 ± 0.04 ng/mL, respectively. Compound 1 on the other hand
exhibited moderate larvicidal against Anopheles gambiae larvae as well as antimicrobial
activities against Candida albicans and gram-positive Staphylococcus aureus, respectively. | en_US |
| dc.publisher | The Korean Society for Applied Biological Chemistry | en_US |
| dc.subject | AlkaloidsAlysicarpus ovalifoliusAntiplasmodialLarvicidalMosquitocidalFabaceae | en_US |
| dc.title | Bioactive carbazole alkaloids from Alysicarpus ovalifolius (Schumach) | en_US |
| dc.type | Article | en_US |
