Show simple item record

dc.contributor.authorAngeline Atieno Ochung, Lawrence Arot Oyango Manguro, Phillip Okinda Owuor, Isaac Ogoche Jondiko, Regina Achieng’Nyunja, Hosea Akala, Pauline Mwinzi, Sylvia Awino Opiyo
dc.date.accessioned2020-07-16T12:02:08Z
dc.date.available2020-07-16T12:02:08Z
dc.date.issued2015-12-01
dc.identifier.urihttps://repository.maseno.ac.ke/handle/123456789/1508
dc.description.abstractPhytochemical and biological evaluation of the stem bark of Alysicarpus ovalifolius led to the isolation of three carbazole alkaloids identified as mohanimbine (1), koenimbine (2) and koenidine (3) along with quercetin 3-O-glucoside (4), kaempferol 7-O-glucoside (5), orientin (6), apigenin (7), quercetin (8), plumbagin (9) and stigmasterol (10). The structures of these compounds were elucidated using physical and spectroscopic methods as well as comparison with the literature data. Compound 3 showed strong activity against chloroquine-sensitive strain I (D6) and the multi-drug resistant Indochicha I (W2) of Plasmodium falciparum with IC50 values of 63.07 ± 0.01 and 54.19 ± 0.04 ng/mL, respectively. Compound 1 on the other hand exhibited moderate larvicidal against Anopheles gambiae larvae as well as antimicrobial activities against Candida albicans and gram-positive Staphylococcus aureus, respectively.en_US
dc.publisherThe Korean Society for Applied Biological Chemistryen_US
dc.subjectAlkaloidsAlysicarpus ovalifoliusAntiplasmodialLarvicidalMosquitocidalFabaceaeen_US
dc.titleBioactive carbazole alkaloids from Alysicarpus ovalifolius (Schumach)en_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record