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Lonchocarpus eriocalyx (Harms) Herb Extract for Use as Painkillers

Show simple item record Atieno Ochung, Angeline Okinda Owuor, Phillip Arot Manguro, Lawrence Ishola, Ismael 2020-07-15T09:29:20Z 2020-07-15T09:29:20Z 2020-02-02
dc.description.abstract Today, many herbal preparations are being prescribed as analgesics. In the past decade, there has been a resurgence of interest in traditional systems of medicine which has become a topic of global interest. Indeed, many important drugs in the market have been obtained directly/ indirectly from natural sources, for example: morphine, pilocarpine, quinine and artemisinin among others. Lonchocarpus eriocalyx (Harms) belongs to the family Fabaceae and is used traditionally to control fever, headache and general body pain. This plant was studied for presence of secondary metabolites and the antinocieceptive effects. Four lupane-type terpenoids; lupeol (1), friedelin (2) stigmasterol (3), and stigmasterol glucoside (4) were isolated from the ethylacetate (EtOAc) extract of leaves by extensive silica gel chromatography and their structures elucidated by spectroscopic 1D and 2D Nuclear Magnetic Resonance (NMR) as well as comparison with literature data. Acetic acid-induced writhing test in mice was used to study the analgesic effect of the crude extract and isolates with Acetyl-salicylic acid as the positive control (87.37%). After prior intraperitoneal injection (i.p) of the mice with the EtOAc extract (100 mg/Kg) and the isolates (10 mg/kg, p.o.), comparatively less number of writhes were observed implying that the extract and isolates had significant ability to relieve pain. Similarly, a percent inhibition of 50.52, 76.7, 66.47 and 62.24% was observed in EtOAc and compounds 1, 2 and 3 respectively compared to the positive control (87.37%). This research has confirmed the presence of painkillers in this plant and scientifically validates its use in folk medicine. The isolates can be used as templates and derivatised into alternative analgesics to support the existing strategies in the management of diseases. Improved health will enhance productivity both at National and Global levels. Large scale cultivation of this plant for commercial purposes will be an Income Generating Activity (IGA) for the rural poor and supplement the strategies aimed at poverty alleviation. en_US
dc.publisher Science Publishing Group en_US
dc.subject Lonchocarpus eriocalyx, Fabaceae, Leaves, Terpenoids, Analgesic Activity en_US
dc.title Lonchocarpus eriocalyx (Harms) Herb Extract for Use as Painkillers en_US
dc.type Article en_US

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