Browsing by Author "Makawiti, Dominic W"
Now showing items 1-17 of 17
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Changes in the concentrations of testosterone, luteinising hormone and progesterone associated with administration of embelin
EK, Githui; Makawiti, Dominic W; JO, Midiwo (Elsevier, 1991-10-01)The mode of action of embelin, a naturally occurring plant benzoquinone with male fertility regulating potential, was investigated. Sexually mature white New Zealand male rabbits were injected intra-muscularly with ... -
Defects in resting metabolic rates and mitochondrial respiration in Kwashiorkor and dietary obese rats
Konji, Victor N; Olowookere, Julius O; Makawiti, Dominic W; Kamau, John MZ; Kiaira, Job K; Omwandho, Charles A (Springer-Verlag, 1991-07-01)Resting metabolic rates have been measured and compared with hepatic mitochondrial respiration in Kwashiorkor and diet-induced obese weaned rats. In Kwashiorkor, resting metabolic rate was 21% lower than the value of ... -
Delayed recovery of adrenocortical and testicular function after chemotherapy of human trypanosomiasis
Kimata, DM; Makawiti, Dominic W; Tengekyon, KM; Dadzie, S; Waindi, EN (Elsevier, 2018)The following indicators of pituitary, adreno-cortical and testicular function were measured in 58 male African trypanosomiasis patients from Western Kenya; plasma cortisol, luteinizing hormone (LH) and testosterone ... -
The effect of l-thyroxine on the anaemia response in Trypanosoma congolense infected rabbits
Makawiti, Dominic W; Okinji, VN; Lomo, Po (Elsevier, 1995-06-01)The development of anaemia is a major pathological manifestation in chronic trypanosomosis. The anaemia in African trypanosomosis coincides with a marked decrease in plasma concentration of both thyroxine (T 4) and 3, ... -
Effect of naturally occurring plant quinones on insect flight muscle mitochondrial respiration
Makawiti, Dominic W; Konji, VN; Magiri, EN (FEDERATION AMER SOC EXP BIOL, 1997-07-31) -
The effect of Trypanosoma vivax infection on late pregnancy and postpartum return to cyclicity in Boran cattle
Watson, ED; Okech, G; Luckins, AG; Makawiti, Dominic W (Elsevier, 1996-10-01)A study was designed to examine the effect of infection with Trypanosoma vivax KETRI 2501 on the maintenance of pregnancy and postpartum return to reproductive function in susceptible Galana (n= 6) and trypano-tolerant ... -
Effects of graded doses of the pesticide heptachlor on body weight, mating success, oestrous cycle, gestation length and litter size in laboratory rats
Oduma, JA; Wango, EO; Makawiti, Dominic W; Jensen, N Einer; D, Oduor-Okelo D (Pergamon, 1995-05-01)Adult female Sprague-Dawley rats were injected with 5 or 20 mg/kg body weight heptachlor solution every other day for up to 18 days. They were weighed every day and the stage of oestrus determined by vaginal smears. ... -
In vitro interstitial (Leydig) cell response to LH and concentrations of plasma testosterone and LH in the naked mole rat (Heterocephalus glaber, Ruppell)
Onyango, DW; GE OTIANGA, OWITI; D ODUOR, OKELO; Makawiti, Dominic W (Blackwell Publishing Ltd, 1991-03-01)Summary Reproductive endocrinology of the male naked mole rat (Heterocephalus glaber) caught in the wild was studied. In vitro treatment of isolated Leydig cells using either normal dose of LH capable of stimulating ... -
In vivo and in vitro effects of graded doses of the pesticide heptachlor on female sex steroid hormone production in rats
Wango, EO; Oduma, JA; Okelo, D Oduor; Makawiti, Dominic W; Odongo, H (Pergamon, 1995-05-01)Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental ... -
Interaction of benzoquinones with mitochondria interferes with oxidative phosphorylation characteristics
Makawiti, Dominic W; Julius O, Olowookere; Konji, Victor N (No longer published by Elsevier, 1990-08-06)Studies with four benzoquinones, viz. juglone, embelin, maesaquinone and maesanin, on rat liver mitochondria oxidative phosphorylation have been carried out. Three of the benzoquinones are uncouplers in the order ... -
Medicinal plants used in the treatment of fungal and bacterial infections in and around Queen Elizabeth Biosphere Reserve, western Uganda
Origa, Hannington O; Mugisha, Maud K; Makawiti, Dominic W; Odyek, Olwa (Blackwell Publishing Ltd, 2008-06-01)In Uganda, bacterial and fungal infections are prevalent especially, the sexually transmitted diseases including HIV/AIDS. Because of low socio-economic empowerment, traditional beliefs and cultural barriers, the ... -
The oxytocic properties of Luffa cylindrica (L.) M. Roem. and Bidens pilosa L., traditionally used medicinal plants from western Uganda
Origa, Hannington O; Maud, Maud K; Makawiti, Dominic W; Nganga, Joseph (Blackwell Publishing Ltd, 2007-12-01)The usage of medicinal plants in childbirth in Uganda is a long standing tradition. Over 80% of Ugandan women have childbirth at home and herbal remedies are administered to complete the process of childbirth. The herbs ... -
The pesticide heptachlor affects steroid hormone secretion in isolated follicular and luteal cells of rat
Oduma, JA; Okelo, D O; Odongo, H; Makawiti, Dominic W (Elsevier, 2006-09-01)Heptachlor, a chlorinated hydrocarbon pesticide, suppresses the production of progesterone and estradiol in the female rat in vivo or in isolated ovaries in vitro. In this study the effect of heptachlor on steroid ... -
Reduced immune complex binding capacity and increased complement susceptibility of red cells from children with severe malaria-associated anemia
Odhiambo, Collins O; Owuor, Boaz O; Adhiambo, Christine; Otieno, Walter O; Makawiti, Dominic W; Stoute, José A (The Feinstein Institute for Medical Research, 2008-03)Plasmodium falciparum malaria causes 1–2 million deaths per year. Most deaths occur as a result of complications such as severe anemia and cerebral malaria (CM)(coma). Red cells of children with severe malaria-associated ... -
Reflections on the first pan‐african conference on biochemistry and molecular biology
Makawiti, Dominic W (Headington Hill Hall, 1997-07-01)After a couple of years of consultations with leading biochemists/molecular biologists in Africa and from abroad (playing advisory roles), the First Pan-African Conference on Biochemistry and Molecular Biology was ... -
Sehistosoma Mansoni in the Baboon: Modulation of Pathology After Vaccination with Polyclonal Anti‐Idiotypic Antibodies
Borus, Pk; Nyindo, M; Farah, IO; Oguya, FO; Makawiti, Dominic W (Blackwell Publishing Ltd, 1995-12-01)Vaccination of five baboons with an anti-idiotypic vaccine to irradiated Schistosoma mansoni cercariae resulted in nearly 19% protection compared to 39% protection conferred to five baboons vaccinated with an irradiated ... -
Thyroid status and adenosine triphosphataseactivity in experimental Trypanosoma congolense infection in rabbits
Lomo, Po; Makawiti, Dominic W; Okinji, VN (Saunders, 1996-11-01)Summary The effect of trypanosome infection on the plasma levels and ratios of tri- iodothyronine (T 3) and thyroxine (T 4) as well as the activity of mitochondrial adenosine triphosphatase (ATPase) were investigated. ...