Browsing by Author "Levin, Mariano J"

Now showing items 1-4 of 4

    • Functional characterization and protein–protein interactions of trypanosome splicing factors U2AF35, U2AF65 and SF1 

      Vazquez, Martin P; Mualem, David; Bercovich, Natalia; Stern, Michael Z; Nyambega, Benson; Barda, Omer; Masiga, Dan; Gupta, Sachin K; Michaeli, Shulamit; Levin, Mariano J (Elsevier, 2009-04-01)
      Early in the assembly of the spliceosome of eukaryotes the branch-point binding protein (BBP, also called SF1) recognizes the branch point sequence, whereas the heterodimer U2AF consisting of a 65 and a 35 kDa subunit, ...

    • Proteins Associated with SF3a60 in T. brucei 

      Nyambega, Benson; Helbig, Claudia; Masiga, Daniel K; Clayton, Christine; Levin, Mariano J (Public Library of Science, 2014-03-20)
      Trypanosoma brucei relies on Spliced leader trans splicing to generate functional messenger RNAs. Trans splicing joins the specialized SL exon from the SL RNA to pre-mRNAs and is mediated by the trans-spliceosome, which ...

    • Protein–protein interaction map of the Trypanosoma cruzi ribosomal P protein complex 

      Ayub, Maximiliano J; Smulski, Cristian R; Nyambega, Benson; Bercovich, Natalia; Masiga, Dan; Vazquez, Martín P; Aguilar, Carlos F; Levin, Mariano J (Elsevier, 2005-09-12)
      The large subunit of the eukaryotic ribosome possesses a long and protruding stalk formed by the ribosomal P proteins. Four out of five ribosomal P proteins of Trypanosoma cruzi, TcP0, TcP1α, TcP2α, and TcP2β had been ...

    • Selective Blockade of Trypanosomatid Protein Synthesis by a Recombinant Antibody Anti-Trypanosoma cruzi P2β Protein 

      Ayub, Maximiliano J; Nyambega, Benson; Simonetti, Leandro; Duffy, Tomas; Longhi, Silvia A; Gómez, Karina A; Hoebeke, Johan; Levin, Mariano J; Smulski, Cristian R (Public Library of Science, 2012-05-03)
      The ribosomal P proteins are located on the stalk of the ribosomal large subunit and play a critical role during the elongation step of protein synthesis. The single chain recombinant antibody C5 (scFv C5) directed against ...