Browsing Department of Medical Biochemistry by Author "A Kayitesi, C Nakkazi, DR Kugonza, MW Okot, H Mulindwa, PM Mshenga, B Mugonola, NP Carsten, MA Olufemi, K Manjur, BA Odogwu, S Nkalubo, P Rubaihayo, E Zhou, J Walls, MP McHenry, D Doepel, JG Howieson, Neema John Mboya, L Tembo, G Asea, Paul T Gibson, P Okori, K Simango, D Lungu, Simon Wambui Mburu, Gilbert Koskey, Jacinta Malia Kimiti, Omwoyo Ombori, John Maingi, Ezekiel Mugendi Njeru, Ezekiel Chepkwony, M Korir, M Kipsat, J Ogembo Oyaro, P Nawiri, W Musila, JP Gweyi Onyango, Simon W Mburu, Jacinta M Kimiti, SB Nchore, JW Waceke, C Buttner, O Omwoyo, C Ulrichs, EW Mugi-Ngenga, MW Mucheru-Muna, JN Mugwe, FK Ngetich, FS Mairura, DN Mugendi, Jane Ndegi Mugambi, Okello Samuel Arum, Mumu Thomas Waithaka, M Okoti, WN Ekaya, JN Mugambi, EW Kairu, BO Danga, B Mochoge, J Mugwe, Z Getenga, P Tangut, R Karega, H Mulindi, T Thoruwa, S Okwach, Peter Okello Odhiambo, M Nabasirye, MM Tenywa, Y Bamutaze, CA Shisanya, MM Nsengiyunva"
Now showing items 1-11 of 11
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(−7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
Okeyo, WA; Munde, EO; Okumu, W; Raballah, E; Anyona, SB; Vulule, JM; Ong’echa, JM; Perkins, DJ; Ouma, C (Bio Med Central, 2013)In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ... -
Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya.
Munde, EO; Okeyo, WA; Raballah, E; Anyona, SB; Were, T; Ong’echa, JM; Perkins, DJ; Ouma, C (BMC infectious diseases, 2017-04)BACKGROUND: Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG) antibodies and mediate phagocytosis of ... -
Factors associated with non-adherence to Artemisinin-based combination therapy (ACT) to malaria in a rural population from holoendemic region of western Kenya.
Onyango, EO; Ayodo, G; Watsierah, CA; Were, T; Okumu, W; Anyona, SB; Raballah, E; Okoth, JM; Gumo, S; Orinda, GO; Ouma, C (Pub Med Central, 2012-06)Background Over the years, reports implicate improper anti-malarial use as a major contributor of morbidity and mortality amongst millions of residents in malaria endemic areas, Kenya included. However, there are limited ... -
Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children.
Ouma, C; Davenport, GC; Garcia, S; Kempaiah, P; Chaudhary, A; Were, T; Anyona, SB; Raballah, E; Konah, SN; Hittner, JB; Vulule., JM; Ong'echa, JM; Perkins, DJ (Pub Med Central, 2012-02)Development of protective immunity against Plasmodium falciparum is partially mediated through binding of malaria-specific IgG to Fc gamma (γ) receptors. Variation in human FcγRIIA-H/R-131 and FcγRIIIB-NA1/NA2 affect ... -
Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality
Anyona, SB; Kempaiah, P; Raballah, E; Ouma, C; Were, T; Davenport, GC; Konah, SN; Vulule, JM; Hittner, JB; Gichuki, CW; Ong'echa, JM; Perkins, DJ (Pub Med Central, 2011-12)Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children residing in regions where Plasmodium falciparum transmission is holoendemic. Although largely unexplored in children with SMA, ... -
Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial.
Waitumbi, JN; Anyona, SB; Hunja, CW; Kifude, CM; Polhemus, ME; Walsh, DS; Ockenhouse, CF; Heppner, DG; Leach, A; Lievens, M; Ballou, WR; Cohen, JD; Sutherland, CJ (Pub Med Central, 2009-11-17)OBJECTIVE: RTS,S, a candidate vaccine for malaria, is a recombinant protein expressed in yeast containing part of the circumsporozoite protein (CSP) sequence of 3D7 strain of Plasmodium falciparum linked to the hepatitis ... -
Malaria prevalence defined by microscopy, antigen detection, DNA amplification and total nucleic acid amplification in a malaria-endemic region during the peak malaria transmission season
Waitumbi, JN; Gerlach, J; Afonina, I; Anyona, SB; Koros, JN; Siangla, J; Ankoudinova, I; Singhal, M; Watts, K; Polhemus, ME; Vermeulen, NM; Mahoney, W; Steele, M; Domingo, GJ (Pub Med Central, 2011-07)OBJECTIVES: To determine the malaria prevalence by microscopy, antigen detection and nucleic acid detection in a defined subpopulation in a Plasmodium falciparum-endemic region during the peak transmission season. ME ... -
Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria
Ong'echa, JM; Raballah, EO; Kempaiah, PM; Anyona, SB; Were, T; Davenport, GC; Konah, S; Vulule, JM; Ouma, C; Hittner, JB; Perkins, DJ (Pub Med Central, 2011-08)BACKGROUND: Plasmodium falciparum malaria remains a leading cause of morbidity and mortality among African children. Innate immunity provides the first line of defence against P. falciparum infections, particularly in young ... -
Reduced interferon (IFN)-α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality
Kempaiah, P; Anyona, SB; Raballah, E; Davenport, GC; Were, T; Hittner, JB; Ong'echa JM, JM; Perkins, DJ (Pub Med Central, 2012-08)Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ... -
Reduced Systemic Bicyclo-Prostaglandin-E2 and Cyclooxygenase-2 Gene Expression are Associated with Inefficient Erythropoiesis and Enhanced Uptake of Monocytic Hemozoin in Children with Severe Malarial Anemia
Anyona, SB; Kempaiah, P; Raballah, E; Davenport, GC; Were, T; Konah, SN; Vulule, JM; Hittner, JB; Gichuki, CW; Ong’echa, JM; Perkins, DJ (Pub Med Central, 2012-08)In holoendemic Plasmodium falciparum transmission areas, severe malaria primarily occurs in children <48 mos. and manifests as severe malarial anemia [SMA; hemoglobin (Hb)<6.0 g/dL]. Induction of high levels of prostaglandin-E2 ... -
Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia.
Anyona, SB; Kempaiah, P; Davenport, GC; Vulule, JM; Hittner, JB; Ong’echa, JM; Perkins, DJ (Biochemical and biophysical research communications, 2013)In holoendemic Plasmodium falciparum transmission regions, malarial anemia is a leading cause of childhood morbidity and mortality. Identifying biomarkers of malaria disease severity is important for identifying at-risk ...