Browsing Department of Medical Biochemistry by Title
Now showing items 52-71 of 282
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Daily home fortification with iron as ferrous fumarate versus NaFeEDTA: a randomised, placebo-controlled, non-inferiority trial in Kenyan children
(BioMed Centra, 2017)Background: We aimed to show the non-inferiority of home fortification with a daily dose of 3 mg iron in the form of iron as ferric sodium ethylenediaminetetraacetate (NaFeEDTA) compared with 12.5 mg iron as encapsulated ferrous ... -
Defects in resting metabolic rates and mitochondrial respiration in Kwashiorkor and dietary obese rats
(Springer-Verlag, 1991-07-01)Resting metabolic rates have been measured and compared with hepatic mitochondrial respiration in Kwashiorkor and diet-induced obese weaned rats. In Kwashiorkor, resting metabolic rate was 21% lower than the value of ... -
Delayed recovery of adrenocortical and testicular function after chemotherapy of human trypanosomiasis
(Elsevier, 2018)The following indicators of pituitary, adreno-cortical and testicular function were measured in 58 male African trypanosomiasis patients from Western Kenya; plasma cortisol, luteinizing hormone (LH) and testosterone ... -
Depletion of trypanosome CTR9 leads to gene expression defects
(Public Library of Science, 2012-04-20)The Paf complex of Opisthokonts and plants contains at least five subunits: Paf1, Cdc73, Rtf1, Ctr9, and Leo1. Mutations in, or loss of Paf complex subunits have been shown to cause defects in histone modification, mRNA ... -
Determinants of adherence to anti-retroviral therapy among discordant couples in Usigu Division, Bondo sub-county, Kenya
(Kenya Medical Association, 2018)Objective: To establish the determinants of adherence to ART among discordant couples in Usigu Division, Bondo sub-County. Design: A descriptive cross-sectional study. Setting: Comprehensive Care Clinics within Usigu ... -
Determinants of antibiotic dose adjustment in patients with chronic kidney disease at Kenyatta National Hospital Kenya
(University of Nairobi, 2014)Background: Reduced renal function in chronic kidney disease (CKD) necessitates appropriate dose alterations to avoid drug accumulation. Objectives: The main objective of the study was to determine the prevalence of ... -
Determinants of Appropriate Antibiotic Dosing in Patients with Chronic Kidney Disease in a Kenyan Referral Hospital
(A KeSoBAP Publication, 2014-12-05)Background: Reduced renal function in chronic kidney disease (CKD) necessitates appropriate dose alterations to avoid drug accumulation. Objectives: The main objective of the study was to determine the prevalence of ... -
Determinants of quality of life among gynaecological cancer patients on follow up at a referral hospital in Kenya
(University of Nairobi, 2015-06-08)Various factors influence the quality of life (QOL) in cancer patients. This study sought to determine the predictors and factors associated with quality of life among g ynaecological cancer patients on follow up at Kenya ... -
Determination of reference intervals for common chemistry and immunoassay tests for Kenyan adults based on an internationally harmonized protocol and up-to-date statistical methods
(Public Library of Science, 2020-07-09)Due to a lack of reliable reference intervals (RIs) for Kenya, we set out to determine RIs for 40 common chemistry and immunoassay tests as part of the IFCC global RI project. -
Diagnostic dose determination and efficacy of chlorfenapyr and clothianidin insecticides against Anopheles malaria vector populations of western Kenya
(BioMed Central, 2019)Background: Malaria vector control is dependent on chemical insecticides applied to walls by indoor residual spraying or on long-lasting insecticidal nets. The emergence and spread of insecticide resistance in major malaria ... -
The differential effect of the free maternity services policy in Kenya
(AOSIS Publishing, 2019)BACKGROUND: The Government of Kenya introduced the free maternity services (FMS) policy to enable mothers deliver at a health facility and thus improve maternal health indicators. AIM: The aim of this study was to determine ... -
Direct detection of bacteremia by exploiting host-pathogen interactions of lipoteichoic acid and lipopolysaccharide
(Nature Publishing Group, 2019-04-17)Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality rates are the highest in the world. The early diagnosis of bacteremia and initiation of treatment saves lives, especially in high-disease ... -
Distinct pattern of class and subclass antibodies in immune complexes of children with cerebral malaria and severe malarial anaemia
(Blackwell Publishing Ltd, 2008)Plasmodium falciparum infection can lead to deadly complications such as severe malaria‐associated anaemia (SMA) and cerebral malaria (CM). Children with severe malaria have elevated levels of circulating immune complexes ... -
Distribution of Biomphalaria Snails in Associated Vegetations and Schistosome Infection Prevalence Along the Shores of Lake Victoria in Mbita, Kenya: A Cross-Sectional Study
(East African Health Research Commission, 2019)Background: Schistosomiasis due to Schistosoma mansoni remains a major public health problem and cause of morbidity and mortality in sub-Saharan Africa despite the implementation of control programmes. More than 6 million ... -
Dual role of erythrocyte complement receptor type 1 in immune complex‐mediated macrophage stimulation: implications for the pathogenesis of Plasmodium falciparum malaria
(Blackwell Publishing Ltd, 2011)iven the ability of erythrocytes to bind immune complexes (ICs), we postulated that they can serve a dual role during inflammatory or infectious processes. Erythrocytes could restrict stimulation of macrophages by free ICs ... -
Duffy Antigen/Receptor for Chemokines (DARC): Is There a Role in Prostate Cancer?.
(American Society of Hematology, 2005-11-16)Introduction: The Duffy blood group antigens function as chemokine receptors and as receptors for several species of malarial parasites. Approximately 70% of African Americans are Duffy negative as a result of a single ... -
Duffy Antigen/Receptor for Chemokines (DARC): Is There a Role in Prostate Cancer?.
(science direct, 2005)Introduction: The Duffy blood group antigens function as chemokine receptors and as receptors for several species of malarial parasites. Approximately 70% of African Americans are Duffy negative as a result of a single ... -
The effect of abdominal obesity on insulin sensitivity and serum lipid and cytokine concentrations in African women
(Blackwell Publishing Ltd, 2006-05)Studies have shown clear associations of abdominal obesity with lipid and glucose metabolism and cytokine levels in a number of different population groups. However, no such studies have been performed in an African ... -
Effect of dental caries and malocclusion on the oral health-related quality of life in 12-14 year old children in Viwandani Slum, Nairobi
(University of Nairobi, Kenya, 2011)Background: Traditional methods of measuring oral health mainly use clinical dental indices. In recent years, the use of subjective assessments to gain information about the impact of oral disorders on Oral-Health Related ...